BDBM274316 3-(1-acetylazetidin-3-yl)-6-(4-chlorophenyl)-5-(3,8-dimethyl-[1,2,4]triazolo[4,3-a]pyridin-6-yl)-1-methyl-5,6-dihydropyrrolo[3,4-b]pyrrol-4(1H)-one::US9550796, Example 117

SMILES: CC(=O)N1CC(C1)c1cn(C)c2C(N(C(=O)c12)c1cc(C)c2nnc(C)n2c1)c1ccc(Cl)cc1

InChI Key: InChIKey=RJDVRXGILIWOCC-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 274316   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Bromodomain-containing protein 4 (Homo sapiens (Human))	BDBM274316 (3-(1-acetylazetidin-3-yl)-6-(4-chlorophenyl)-5-(3,...) Show SMILES CC(=O)N1CC(C1)c1cn(C)c2C(N(C(=O)c12)c1cc(C)c2nnc(C)n2c1)c1ccc(Cl)cc1 Show InChI InChI=1S/C26H25ClN6O2/c1-14-9-20(12-32-15(2)28-29-25(14)32)33-23(17-5-7-19(27)8-6-17)24-22(26(33)35)21(13-30(24)4)18-10-31(11-18)16(3)34/h5-9,12-13,18,23H,10-11H2,1-4H3	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	14	n/a	n/a	n/a	n/a	7.5	n/a
NOVARTIS AG US Patent					Assay Description All assays were performed in 384-well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...				US Patent US9550796 (2017) BindingDB Entry DOI: 10.7270/Q2QN68SK
					More data for this Ligand-Target Pair
CREB-binding protein (Homo sapiens (Human))	BDBM274316 (3-(1-acetylazetidin-3-yl)-6-(4-chlorophenyl)-5-(3,...) Show SMILES CC(=O)N1CC(C1)c1cn(C)c2C(N(C(=O)c12)c1cc(C)c2nnc(C)n2c1)c1ccc(Cl)cc1 Show InChI InChI=1S/C26H25ClN6O2/c1-14-9-20(12-32-15(2)28-29-25(14)32)33-23(17-5-7-19(27)8-6-17)24-22(26(33)35)21(13-30(24)4)18-10-31(11-18)16(3)34/h5-9,12-13,18,23H,10-11H2,1-4H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.37E+4	n/a	n/a	n/a	n/a	7.5	30
NOVARTIS AG US Patent					Assay Description All assays were performed in 384-well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...				US Patent US9550796 (2017) BindingDB Entry DOI: 10.7270/Q2QN68SK
					More data for this Ligand-Target Pair
Bromodomain-containing protein 3 (Homo sapiens (Human))	BDBM274316 (3-(1-acetylazetidin-3-yl)-6-(4-chlorophenyl)-5-(3,...) Show SMILES CC(=O)N1CC(C1)c1cn(C)c2C(N(C(=O)c12)c1cc(C)c2nnc(C)n2c1)c1ccc(Cl)cc1 Show InChI InChI=1S/C26H25ClN6O2/c1-14-9-20(12-32-15(2)28-29-25(14)32)33-23(17-5-7-19(27)8-6-17)24-22(26(33)35)21(13-30(24)4)18-10-31(11-18)16(3)34/h5-9,12-13,18,23H,10-11H2,1-4H3	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	17	n/a	n/a	n/a	n/a	7.5	n/a
NOVARTIS AG US Patent					Assay Description All assays were performed in 384-well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...				US Patent US9550796 (2017) BindingDB Entry DOI: 10.7270/Q2QN68SK
					More data for this Ligand-Target Pair