BDBM27487 2-amino-3-(4-{[3-(dimethylamino)propyl]sulfamoyl}phenyl)-5-phenylbenzamide::Amino-substituted diarylbenzamide, 8t

SMILES: CN(C)CCCNS(=O)(=O)c1ccc(cc1)-c1cc(cc(C(N)=O)c1N)-c1ccccc1

InChI Key: InChIKey=QXSYSNADTWMERQ-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 27487   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Inhibitor of nuclear factor kappa-B kinase subunit alpha (Homo sapiens (Human))	BDBM27487 (2-amino-3-(4-{[3-(dimethylamino)propyl]sulfamoyl}p...) Show SMILES CN(C)CCCNS(=O)(=O)c1ccc(cc1)-c1cc(cc(C(N)=O)c1N)-c1ccccc1 Show InChI InChI=1S/C24H28N4O3S/c1-28(2)14-6-13-27-32(30,31)20-11-9-18(10-12-20)21-15-19(17-7-4-3-5-8-17)16-22(23(21)25)24(26)29/h3-5,7-12,15-16,27H,6,13-14,25H2,1-2H3,(H2,26,29)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description IKK kinase activity was assessed using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The reaction was initiated by the addi...				Bioorg Med Chem Lett 17: 3972-7 (2007) Article DOI: 10.1016/j.bmcl.2007.04.088 BindingDB Entry DOI: 10.7270/Q2QZ289W
					More data for this Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit epsilon (Homo sapiens (Human))	BDBM27487 (2-amino-3-(4-{[3-(dimethylamino)propyl]sulfamoyl}p...) Show SMILES CN(C)CCCNS(=O)(=O)c1ccc(cc1)-c1cc(cc(C(N)=O)c1N)-c1ccccc1 Show InChI InChI=1S/C24H28N4O3S/c1-28(2)14-6-13-27-32(30,31)20-11-9-18(10-12-20)21-15-19(17-7-4-3-5-8-17)16-22(23(21)25)24(26)29/h3-5,7-12,15-16,27H,6,13-14,25H2,1-2H3,(H2,26,29)	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.58E+4	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description IKK kinase activity was assessed using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The reaction was initiated by the addi...				Bioorg Med Chem Lett 17: 3972-7 (2007) Article DOI: 10.1016/j.bmcl.2007.04.088 BindingDB Entry DOI: 10.7270/Q2QZ289W
					More data for this Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta (Homo sapiens (Human))	BDBM27487 (2-amino-3-(4-{[3-(dimethylamino)propyl]sulfamoyl}p...) Show SMILES CN(C)CCCNS(=O)(=O)c1ccc(cc1)-c1cc(cc(C(N)=O)c1N)-c1ccccc1 Show InChI InChI=1S/C24H28N4O3S/c1-28(2)14-6-13-27-32(30,31)20-11-9-18(10-12-20)21-15-19(17-7-4-3-5-8-17)16-22(23(21)25)24(26)29/h3-5,7-12,15-16,27H,6,13-14,25H2,1-2H3,(H2,26,29)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	316	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description IKK kinase activity was assessed using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The reaction was initiated by the addi...				Bioorg Med Chem Lett 17: 3972-7 (2007) Article DOI: 10.1016/j.bmcl.2007.04.088 BindingDB Entry DOI: 10.7270/Q2QZ289W
					More data for this Ligand-Target Pair