BDBM27488 2-amino-3-(4-{[3-(morpholin-4-yl)propyl]sulfamoyl}phenyl)-5-phenylbenzamide::Amino-substituted diarylbenzamide, 8u

SMILES: NC(=O)c1cc(cc(c1N)-c1ccc(cc1)S(=O)(=O)NCCCN1CCOCC1)-c1ccccc1

InChI Key: InChIKey=YVHUOVHVRVMPMH-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 27488   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Inhibitor of nuclear factor kappa-B kinase subunit alpha (Homo sapiens (Human))	BDBM27488 (2-amino-3-(4-{[3-(morpholin-4-yl)propyl]sulfamoyl}...) Show SMILES NC(=O)c1cc(cc(c1N)-c1ccc(cc1)S(=O)(=O)NCCCN1CCOCC1)-c1ccccc1 Show InChI InChI=1S/C26H30N4O4S/c27-25-23(17-21(18-24(25)26(28)31)19-5-2-1-3-6-19)20-7-9-22(10-8-20)35(32,33)29-11-4-12-30-13-15-34-16-14-30/h1-3,5-10,17-18,29H,4,11-16,27H2,(H2,28,31)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description IKK kinase activity was assessed using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The reaction was initiated by the addi...				Bioorg Med Chem Lett 17: 3972-7 (2007) Article DOI: 10.1016/j.bmcl.2007.04.088 BindingDB Entry DOI: 10.7270/Q2QZ289W
					More data for this Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit epsilon (Homo sapiens (Human))	BDBM27488 (2-amino-3-(4-{[3-(morpholin-4-yl)propyl]sulfamoyl}...) Show SMILES NC(=O)c1cc(cc(c1N)-c1ccc(cc1)S(=O)(=O)NCCCN1CCOCC1)-c1ccccc1 Show InChI InChI=1S/C26H30N4O4S/c27-25-23(17-21(18-24(25)26(28)31)19-5-2-1-3-6-19)20-7-9-22(10-8-20)35(32,33)29-11-4-12-30-13-15-34-16-14-30/h1-3,5-10,17-18,29H,4,11-16,27H2,(H2,28,31)	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.58E+4	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description IKK kinase activity was assessed using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The reaction was initiated by the addi...				Bioorg Med Chem Lett 17: 3972-7 (2007) Article DOI: 10.1016/j.bmcl.2007.04.088 BindingDB Entry DOI: 10.7270/Q2QZ289W
					More data for this Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta (Homo sapiens (Human))	BDBM27488 (2-amino-3-(4-{[3-(morpholin-4-yl)propyl]sulfamoyl}...) Show SMILES NC(=O)c1cc(cc(c1N)-c1ccc(cc1)S(=O)(=O)NCCCN1CCOCC1)-c1ccccc1 Show InChI InChI=1S/C26H30N4O4S/c27-25-23(17-21(18-24(25)26(28)31)19-5-2-1-3-6-19)20-7-9-22(10-8-20)35(32,33)29-11-4-12-30-13-15-34-16-14-30/h1-3,5-10,17-18,29H,4,11-16,27H2,(H2,28,31)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	316	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description IKK kinase activity was assessed using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The reaction was initiated by the addi...				Bioorg Med Chem Lett 17: 3972-7 (2007) Article DOI: 10.1016/j.bmcl.2007.04.088 BindingDB Entry DOI: 10.7270/Q2QZ289W
					More data for this Ligand-Target Pair