BDBM275797 5-chloro-4-((5-chloro- 6-isobutoxypyridin- 3-yl)oxy)-2-fluoro- N-(pyrrolidin-1- ylsulfonyl)benzamide::US10071957, Example 14
SMILES: CC(C)COc1ncc(Oc2cc(F)c(cc2Cl)C(=O)NS(=O)(=O)N2CCCC2)cc1Cl
InChI Key: InChIKey=ZKEIWRLJUHLQBC-UHFFFAOYSA-N
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human)) | BDBM275797 (5-chloro-4-((5-chloro- 6-isobutoxypyridin- 3-yl)ox...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 30.1 | n/a | n/a | n/a | n/a | 7.4 | 25 |
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent | Assay Description Preparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant cell pellets were thawed on ice and diluted to 4 time... | US Patent US10071957 (2018) BindingDB Entry DOI: 10.7270/Q2J1056P | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human)) | BDBM275797 (5-chloro-4-((5-chloro- 6-isobutoxypyridin- 3-yl)ox...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 44 | n/a | n/a | n/a | n/a | 7.2 | n/a |
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent | Assay Description Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and... | US Patent US10071957 (2018) BindingDB Entry DOI: 10.7270/Q2J1056P | |||||||||||
More data for this Ligand-Target Pair |