null

SMILES: CC(C)COc1ncc(Oc2cc(F)c(cc2Cl)C(=O)NS(=O)(=O)c2c[nH]cn2)cc1Cl

InChI Key: InChIKey=SYKGVYUTMUAYJI-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 275809   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM275809 (N-((1H-imidazol-4- yl)sulfonyl)-5-chloro- 4-((5-ch...) Show SMILES CC(C)COc1ncc(Oc2cc(F)c(cc2Cl)C(=O)NS(=O)(=O)c2c[nH]cn2)cc1Cl Show InChI InChI=1S/C19H17Cl2FN4O5S/c1-10(2)8-30-19-14(21)3-11(6-24-19)31-16-5-15(22)12(4-13(16)20)18(27)26-32(28,29)17-7-23-9-25-17/h3-7,9-10H,8H2,1-2H3,(H,23,25)(H,26,27)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	77.3	n/a	n/a	n/a	n/a	7.4	25
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description Preparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant cell pellets were thawed on ice and diluted to 4 time...				US Patent US10071957 (2018) BindingDB Entry DOI: 10.7270/Q2J1056P
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM275809 (N-((1H-imidazol-4- yl)sulfonyl)-5-chloro- 4-((5-ch...) Show SMILES CC(C)COc1ncc(Oc2cc(F)c(cc2Cl)C(=O)NS(=O)(=O)c2c[nH]cn2)cc1Cl Show InChI InChI=1S/C19H17Cl2FN4O5S/c1-10(2)8-30-19-14(21)3-11(6-24-19)31-16-5-15(22)12(4-13(16)20)18(27)26-32(28,29)17-7-23-9-25-17/h3-7,9-10H,8H2,1-2H3,(H,23,25)(H,26,27)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	9	n/a	n/a	n/a	n/a	7.2	n/a
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...				US Patent US10071957 (2018) BindingDB Entry DOI: 10.7270/Q2J1056P
					More data for this Ligand-Target Pair