BDBM275821 5-chloro-4-(((5-chloro- 6-(2,2,3,3-tetrafluoro- propoxy)pyridin- 3-yl)oxy)methyl)- N-(N,N-dimethyl- sulfamoyl)-2-fluoro- benzamide::US10071957, Example 39::US10071957, Example 76

SMILES: CN(C)S(=O)(=O)NC(=O)c1cc(Cl)c(COc2cnc(OCC(F)(F)C(F)F)c(Cl)c2)cc1F

InChI Key: InChIKey=JWJGDFKYGVLSIF-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 275821   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM275821 (5-chloro-4-(((5-chloro- 6-(2,2,3,3-tetrafluoro- pr...) Show SMILES CN(C)S(=O)(=O)NC(=O)c1cc(Cl)c(COc2cnc(OCC(F)(F)C(F)F)c(Cl)c2)cc1F Show InChI InChI=1S/C18H16Cl2F5N3O5S/c1-28(2)34(30,31)27-15(29)11-5-12(19)9(3-14(11)21)7-32-10-4-13(20)16(26-6-10)33-8-18(24,25)17(22)23/h3-6,17H,7-8H2,1-2H3,(H,27,29)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	216	n/a	n/a	n/a	n/a	7.4	25
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description Preparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant cell pellets were thawed on ice and diluted to 4 time...				US Patent US10071957 (2018) BindingDB Entry DOI: 10.7270/Q2J1056P
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM275821 (5-chloro-4-(((5-chloro- 6-(2,2,3,3-tetrafluoro- pr...) Show SMILES CN(C)S(=O)(=O)NC(=O)c1cc(Cl)c(COc2cnc(OCC(F)(F)C(F)F)c(Cl)c2)cc1F Show InChI InChI=1S/C18H16Cl2F5N3O5S/c1-28(2)34(30,31)27-15(29)11-5-12(19)9(3-14(11)21)7-32-10-4-13(20)16(26-6-10)33-8-18(24,25)17(22)23/h3-6,17H,7-8H2,1-2H3,(H,27,29)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	220	n/a	n/a	n/a	n/a	7.4	25
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description Preparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant cell pellets were thawed on ice and diluted to 4 time...				US Patent US10071957 (2018) BindingDB Entry DOI: 10.7270/Q2J1056P
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM275821 (5-chloro-4-(((5-chloro- 6-(2,2,3,3-tetrafluoro- pr...) Show SMILES CN(C)S(=O)(=O)NC(=O)c1cc(Cl)c(COc2cnc(OCC(F)(F)C(F)F)c(Cl)c2)cc1F Show InChI InChI=1S/C18H16Cl2F5N3O5S/c1-28(2)34(30,31)27-15(29)11-5-12(19)9(3-14(11)21)7-32-10-4-13(20)16(26-6-10)33-8-18(24,25)17(22)23/h3-6,17H,7-8H2,1-2H3,(H,27,29)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	34.3	n/a	n/a	n/a	n/a	7.2	n/a
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...				US Patent US10071957 (2018) BindingDB Entry DOI: 10.7270/Q2J1056P
					More data for this Ligand-Target Pair