BDBM275828 N-(azetidin-1- ylsulfonyl)-5-chloro- 4-((5-chloro-6-iso- butoxypyridin-3- yl)oxy)-2- fluorobenzamide::US10071957, Example 46

SMILES: CC(C)COc1ncc(Oc2cc(F)c(cc2Cl)C(=O)NS(=O)(=O)N2CCC2)cc1Cl

InChI Key: InChIKey=FJDOVVBUORUIFD-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 275828   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM275828 (N-(azetidin-1- ylsulfonyl)-5-chloro- 4-((5-chloro-...) Show SMILES CC(C)COc1ncc(Oc2cc(F)c(cc2Cl)C(=O)NS(=O)(=O)N2CCC2)cc1Cl Show InChI InChI=1S/C19H20Cl2FN3O5S/c1-11(2)10-29-19-15(21)6-12(9-23-19)30-17-8-16(22)13(7-14(17)20)18(26)24-31(27,28)25-4-3-5-25/h6-9,11H,3-5,10H2,1-2H3,(H,24,26)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	9.20	n/a	n/a	n/a	n/a	7.4	25
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description Preparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant cell pellets were thawed on ice and diluted to 4 time...				US Patent US10071957 (2018) BindingDB Entry DOI: 10.7270/Q2J1056P
					More data for this Ligand-Target Pair