BDBM275860 US10071957, Example 79

SMILES: Fc1cc(COc2ccc(OC(F)(F)F)c(Cl)c2)c(Cl)cc1C(=O)NS(=O)(=O)N1CCC1

InChI Key: InChIKey=IRFFMAZTMLXOLP-UHFFFAOYSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 275860   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM275860 (US10071957, Example 79) Show SMILES Fc1cc(COc2ccc(OC(F)(F)F)c(Cl)c2)c(Cl)cc1C(=O)NS(=O)(=O)N1CCC1 Show InChI InChI=1S/C18H14Cl2F4N2O5S/c19-13-8-12(17(27)25-32(28,29)26-4-1-5-26)15(21)6-10(13)9-30-11-2-3-16(14(20)7-11)31-18(22,23)24/h2-3,6-8H,1,4-5,9H2,(H,25,27)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	17	n/a	n/a	n/a	n/a	7.4	25
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description Preparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant cell pellets were thawed on ice and diluted to 4 time...				US Patent US10071957 (2018) BindingDB Entry DOI: 10.7270/Q2J1056P
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