BDBM275864 US10071957, Example 83

SMILES: CNS(=O)(=O)NC(=O)c1ccc(Oc2cnc(OC(C)C)c(Cl)c2)c(c1)-c1cccnc1OC

InChI Key: InChIKey=IOHMBULHSBRPNR-UHFFFAOYSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 275864   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM275864 (US10071957, Example 83) Show SMILES CNS(=O)(=O)NC(=O)c1ccc(Oc2cnc(OC(C)C)c(Cl)c2)c(c1)-c1cccnc1OC Show InChI InChI=1S/C22H23ClN4O6S/c1-13(2)32-22-18(23)11-15(12-26-22)33-19-8-7-14(20(28)27-34(29,30)24-3)10-17(19)16-6-5-9-25-21(16)31-4/h5-13,24H,1-4H3,(H,27,28)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	43	n/a	n/a	n/a	n/a	7.4	25
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description Preparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant cell pellets were thawed on ice and diluted to 4 time...				US Patent US10071957 (2018) BindingDB Entry DOI: 10.7270/Q2J1056P
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