BDBM275869 US10071957, Example 88

SMILES: CC(C)Oc1ncc(Oc2cc(F)c(cc2C2(F)COC2)C(=O)NS(=O)(=O)N2CCC2)cc1Cl

InChI Key: InChIKey=WUTKWSIWXBTHRU-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 275869   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM275869 (US10071957, Example 88) Show SMILES CC(C)Oc1ncc(Oc2cc(F)c(cc2C2(F)COC2)C(=O)NS(=O)(=O)N2CCC2)cc1Cl Show InChI InChI=1S/C21H22ClF2N3O6S/c1-12(2)32-20-16(22)6-13(9-25-20)33-18-8-17(23)14(7-15(18)21(24)10-31-11-21)19(28)26-34(29,30)27-4-3-5-27/h6-9,12H,3-5,10-11H2,1-2H3,(H,26,28)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	44	n/a	n/a	n/a	n/a	7.4	25
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description Preparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant cell pellets were thawed on ice and diluted to 4 time...				US Patent US10071957 (2018) BindingDB Entry DOI: 10.7270/Q2J1056P
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