BDBM275875 US10071957, Example 94

SMILES: Fc1cc(Oc2cnc(OCC(F)(F)F)c(Cl)c2)c(cc1C(=O)NS(=O)(=O)N1CCC1)C1CC1

InChI Key: InChIKey=QGVBHWDTSAAKKV-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 275875   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM275875 (US10071957, Example 94) Show SMILES Fc1cc(Oc2cnc(OCC(F)(F)F)c(Cl)c2)c(cc1C(=O)NS(=O)(=O)N1CCC1)C1CC1 Show InChI InChI=1S/C20H18ClF4N3O5S/c21-15-6-12(9-26-19(15)32-10-20(23,24)25)33-17-8-16(22)14(7-13(17)11-2-3-11)18(29)27-34(30,31)28-4-1-5-28/h6-9,11H,1-5,10H2,(H,27,29)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	9	n/a	n/a	n/a	n/a	7.4	25
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description Preparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant cell pellets were thawed on ice and diluted to 4 time...				US Patent US10071957 (2018) BindingDB Entry DOI: 10.7270/Q2J1056P
					More data for this Ligand-Target Pair