BDBM276119 2-[[1-[4-Chloro-3-(difluoromethoxy)phenyl]triazol-4-yl]methoxy]-5-::US10071988, Example 26::US10233173, Example 26
SMILES: COc1cnc(OCc2cn(nn2)-c2ccc(Cl)c(OC(F)F)c2)nc1
InChI Key: InChIKey=NARKKHZRYMODKR-UHFFFAOYSA-N
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
GluN1/GluN2B NMDA receptor (Homo sapiens (Human)) | BDBM276119 (2-[[1-[4-Chloro-3-(difluoromethoxy)phenyl]triazol-...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Lund University | Assay Description NMDA receptors are ion channels that are highly permeable to Ca2+ ions, rendering it possible to monitor NMDA receptor function using cell-based calc... | Bioorg Med Chem 14: 1215-20 (2006) BindingDB Entry DOI: 10.7270/Q23R0W6K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Retinoic acid receptor RXR-alpha (Homo sapiens (Human)) | BDBM276119 (2-[[1-[4-Chloro-3-(difluoromethoxy)phenyl]triazol-...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 3 | n/a | n/a | n/a | n/a | 7.4 | 25 |
JANSSEN PHARMACEUTICA NV US Patent | Assay Description NMDA receptors are ion channels that are highly permeable to Ca2+ ions, rendering it possible to monitor NMDA receptor function using cell-based calc... | US Patent US10071988 (2018) BindingDB Entry DOI: 10.7270/Q20Z7591 | |||||||||||
More data for this Ligand-Target Pair |