BDBM276729 5-Methoxy-2-((1-(5-(trifluoromethyl)thiophen-2-yl)-1H-1,2,3-triazol-4-::US10071988, Example 669::US10233173, Example 669

SMILES: COc1cnc(OCc2cn(nn2)-c2ccc(s2)C(F)(F)F)nc1

InChI Key: InChIKey=PXUSAZKYODEGMC-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 276729   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
GluN1/GluN2B NMDA receptor (Homo sapiens (Human))	BDBM276729 (5-Methoxy-2-((1-(5-(trifluoromethyl)thiophen-2-yl)...) Show SMILES COc1cnc(OCc2cn(nn2)-c2ccc(s2)C(F)(F)F)nc1 Show InChI InChI=1S/C13H10F3N5O2S/c1-22-9-4-17-12(18-5-9)23-7-8-6-21(20-19-8)11-3-2-10(24-11)13(14,15)16/h2-6H,7H2,1H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
Lund University					Assay Description NMDA receptors are ion channels that are highly permeable to Ca2+ ions, rendering it possible to monitor NMDA receptor function using cell-based calc...				Bioorg Med Chem 14: 1215-20 (2006) BindingDB Entry DOI: 10.7270/Q23R0W6K
					More data for this Ligand-Target Pair
Retinoic acid receptor RXR-alpha (Homo sapiens (Human))	BDBM276729 (5-Methoxy-2-((1-(5-(trifluoromethyl)thiophen-2-yl)...) Show SMILES COc1cnc(OCc2cn(nn2)-c2ccc(s2)C(F)(F)F)nc1 Show InChI InChI=1S/C13H10F3N5O2S/c1-22-9-4-17-12(18-5-9)23-7-8-6-21(20-19-8)11-3-2-10(24-11)13(14,15)16/h2-6H,7H2,1H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4	n/a	n/a	n/a	n/a	7.4	25
JANSSEN PHARMACEUTICA NV US Patent					Assay Description NMDA receptors are ion channels that are highly permeable to Ca2+ ions, rendering it possible to monitor NMDA receptor function using cell-based calc...				US Patent US10071988 (2018) BindingDB Entry DOI: 10.7270/Q20Z7591
					More data for this Ligand-Target Pair