BDBM277102 (S) or (R)-8-methyl-7- {[1-(1-methylethyl)-1H- pyrazol-5-yl]methyl}-4- piperidin-1-yl-5,6,7,8- tetrahydro-1,7- naphthyridine-2- carboxamide::US10072003, Example 1-19
SMILES: CC(C)n1nccc1CN1CCc2c(cc(nc2C1C)C(N)=O)N1CCCCC1
InChI Key: InChIKey=RXCSWMPSKALJOR-UHFFFAOYSA-N
Data: 1 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Metabotropic glutamate receptor 2 (Homo sapiens (Human)) | BDBM277102 ((S) or (R)-8-methyl-7- {[1-(1-methylethyl)-1H- pyr...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.32E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA US Patent | Assay Description The utility of the compounds of the invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demon... | US Patent US10072003 (2018) BindingDB Entry DOI: 10.7270/Q23R0VXK | |||||||||||
More data for this Ligand-Target Pair |