BDBM277677 2-(2-(2-(3-((4-((4-(3-(5-(tert-Butyl)-2-methoxy)-3-(methylsulfonamido)phenyl)ureido-naphthalen-1-yl)oxy)pyridin-2-yl)amino-5-methoxyphenoxy)ethoxy)ethoxy)acetic acid::US10072034, Example 3
SMILES: COc1cc(Nc2cc(Oc3ccc(NC(=O)Nc4cc(cc(NS(C)(=O)=O)c4OC)C(C)(C)C)c4ccccc34)ccn2)cc(OCCOCCOCC(O)=O)c1
InChI Key: InChIKey=HKSWAIDHHZHZTD-UHFFFAOYSA-N
Data: 6 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
5-hydroxytryptamine receptor 2A (Homo sapiens (Human)) | BDBM277677 (2-(2-(2-(3-((4-((4-(3-(5-(tert-Butyl)-2-methoxy)-3...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 23 | n/a | n/a | n/a | n/a | n/a | n/a |
Respivert Limited; Topivert Pharma Limited US Patent | Assay Description The inhibitory activities of test compounds against the p38 MAPKα isoform (MAPK14: Invitrogen) are evaluated indirectly by determining the level... | US Patent US10072034 (2018) BindingDB Entry DOI: 10.7270/Q2B85B49 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human)) | BDBM277677 (2-(2-(2-(3-((4-((4-(3-(5-(tert-Butyl)-2-methoxy)-3...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 18 | n/a | n/a | n/a | n/a | n/a | n/a |
Respivert Limited; Topivert Pharma Limited US Patent | Assay Description The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), are evaluated in a similar fashion to that descri... | US Patent US10072034 (2018) BindingDB Entry DOI: 10.7270/Q2B85B49 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tumor necrosis factor (Homo sapiens (Human)) | BDBM277677 (2-(2-(2-(3-((4-((4-(3-(5-(tert-Butyl)-2-methoxy)-3...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 10.8 | n/a | n/a | n/a | n/a | n/a | n/a |
Respivert Limited; Topivert Pharma Limited US Patent | Assay Description PBMCs from healthy subjects are separated from whole blood using a density gradient (Lymphoprep, Axis-Shield Healthcare). Cells are added to a 96 wel... | US Patent US10072034 (2018) BindingDB Entry DOI: 10.7270/Q2B85B49 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Interleukin-8 (Homo sapiens (Human)) | BDBM277677 (2-(2-(2-(3-((4-((4-(3-(5-(tert-Butyl)-2-methoxy)-3...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 17.3 | n/a | n/a | n/a | n/a | n/a | n/a |
Respivert Limited; Topivert Pharma Limited US Patent | Assay Description PBMCs from healthy subjects are separated from whole blood using a density gradient (Lymphoprep, Axis-Shield Healthcare). Cells are added to a 96 wel... | US Patent US10072034 (2018) BindingDB Entry DOI: 10.7270/Q2B85B49 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Interferon gamma receptor 1 (Homo sapiens (Human)) | BDBM277677 (2-(2-(2-(3-((4-((4-(3-(5-(tert-Butyl)-2-methoxy)-3...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 31.8 | n/a | n/a | n/a | n/a | n/a | n/a |
Respivert Limited; Topivert Pharma Limited US Patent | Assay Description PBMCs from healthy subjects are separated from whole blood using a density gradient (Lymphoprep, Axis-Shield Healthcare). Cells are added to a 96 wel... | US Patent US10072034 (2018) BindingDB Entry DOI: 10.7270/Q2B85B49 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase SYK (Homo sapiens (Human)) | BDBM277677 (2-(2-(2-(3-((4-((4-(3-(5-(tert-Butyl)-2-methoxy)-3...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
Respivert Limited; Topivert Pharma Limited US Patent | Assay Description The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), are evaluated in a similar fashion to that descri... | US Patent US10072034 (2018) BindingDB Entry DOI: 10.7270/Q2B85B49 | |||||||||||
More data for this Ligand-Target Pair |