BDBM277678 2-(2-(2-(3-((4-((4-(3-(5-(tert-Butyl)-2-methoxy-3-(methylsulfonamido)phenyl)ureido)-naphthalen-1-yl)oxy)pyridin-2-yl)amino)-5-methoxybenzamido)ethoxy)ethoxy)acetic acid, hydrochloride salt::US10072034, Example 1

SMILES: COc1cc(Nc2cc(Oc3ccc(NC(=O)Nc4cc(cc(NS(C)(=O)=O)c4OC)C(C)(C)C)c4ccccc34)ccn2)cc(c1)C(=O)NCCOCCOCC(O)=O

InChI Key: InChIKey=AHEGBMOAXKSDLR-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 277678   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Interleukin-8 (Homo sapiens (Human))	BDBM277678 (2-(2-(2-(3-((4-((4-(3-(5-(tert-Butyl)-2-methoxy-3-...) Show SMILES COc1cc(Nc2cc(Oc3ccc(NC(=O)Nc4cc(cc(NS(C)(=O)=O)c4OC)C(C)(C)C)c4ccccc34)ccn2)cc(c1)C(=O)NCCOCCOCC(O)=O Show InChI InChI=1S/C42H48N6O11S/c1-42(2,3)27-21-34(39(56-5)35(22-27)48-60(6,53)54)47-41(52)46-33-11-12-36(32-10-8-7-9-31(32)33)59-29-13-14-43-37(24-29)45-28-19-26(20-30(23-28)55-4)40(51)44-15-16-57-17-18-58-25-38(49)50/h7-14,19-24,48H,15-18,25H2,1-6H3,(H,43,45)(H,44,51)(H,49,50)(H2,46,47,52)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	115	n/a	n/a	n/a	n/a	n/a	n/a
Respivert Limited; Topivert Pharma Limited US Patent					Assay Description PBMCs from healthy subjects are separated from whole blood using a density gradient (Lymphoprep, Axis-Shield Healthcare). Cells are added to a 96 wel...				US Patent US10072034 (2018) BindingDB Entry DOI: 10.7270/Q2B85B49
					More data for this Ligand-Target Pair