BDBM277680 2-(2-(2-(3-((4-((4-(3-(5-tert-Butyl-2-methoxy-3-(methylsulfonamidophenyl)ureido)-naphthalen-1-yl)oxy)pyridin-2-yl)amino)-5-methoxyphenoxy)ethoxy)ethoxy)-N-(methylsulfonyl)acetamide::US10072034, Example 6

SMILES: COc1cc(Nc2cc(Oc3ccc(NC(=O)Nc4cc(cc(NS(C)(=O)=O)c4OC)C(C)(C)C)c4ccccc34)ccn2)cc(OCCOCCOCC(=O)NS(C)(=O)=O)c1

InChI Key: InChIKey=GTKCNILTXVLAMC-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 277680   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Interleukin-8 (Homo sapiens (Human))	BDBM277680 (2-(2-(2-(3-((4-((4-(3-(5-tert-Butyl-2-methoxy-3-(m...) Show SMILES COc1cc(Nc2cc(Oc3ccc(NC(=O)Nc4cc(cc(NS(C)(=O)=O)c4OC)C(C)(C)C)c4ccccc34)ccn2)cc(OCCOCCOCC(=O)NS(C)(=O)=O)c1 Show InChI InChI=1S/C42H50N6O12S2/c1-42(2,3)27-20-35(40(56-5)36(21-27)47-61(6,51)52)46-41(50)45-34-12-13-37(33-11-9-8-10-32(33)34)60-29-14-15-43-38(25-29)44-28-22-30(55-4)24-31(23-28)59-19-18-57-16-17-58-26-39(49)48-62(7,53)54/h8-15,20-25,47H,16-19,26H2,1-7H3,(H,43,44)(H,48,49)(H2,45,46,50)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	18.1	n/a	n/a	n/a	n/a	n/a	n/a
Respivert Limited; Topivert Pharma Limited US Patent					Assay Description PBMCs from healthy subjects are separated from whole blood using a density gradient (Lymphoprep, Axis-Shield Healthcare). Cells are added to a 96 wel...				US Patent US10072034 (2018) BindingDB Entry DOI: 10.7270/Q2B85B49
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