BDBM27916 8-cyclohexyl-N-methoxy-2-{[4-(1-methylpiperidin-4-yl)phenyl]amino}-5-oxo-5H,8H-pyrido[2,3-d]pyrimidine-6-carboxamide::Pyrido[2,3-d]pyrimidin-5-one, 49

SMILES: CONC(=O)c1cn(C2CCCCC2)c2nc(Nc3ccc(cc3)C3CCN(C)CC3)ncc2c1=O

InChI Key: InChIKey=HMRDXCZNJVAJQN-UHFFFAOYSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 27916   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Macrophage colony stimulating factor receptor (Homo sapiens (Human))	BDBM27916 (8-cyclohexyl-N-methoxy-2-{[4-(1-methylpiperidin-4-...) Show SMILES CONC(=O)c1cn(C2CCCCC2)c2nc(Nc3ccc(cc3)C3CCN(C)CC3)ncc2c1=O Show InChI InChI=1S/C27H34N6O3/c1-32-14-12-19(13-15-32)18-8-10-20(11-9-18)29-27-28-16-22-24(34)23(26(35)31-36-2)17-33(25(22)30-27)21-6-4-3-5-7-21/h8-11,16-17,19,21H,3-7,12-15H2,1-2H3,(H,31,35)(H,28,29,30)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	7.5	22
Johnson & Johnson Pharmaceutical					Assay Description FMS was assayed using a fluorescence polarization (FP) competition immunoassay that measured FMS phosphorylation of FMS 555-568 peptide at Y561. The ...				J Med Chem 52: 1081-99 (2009) Article DOI: 10.1021/jm801406h BindingDB Entry DOI: 10.7270/Q21834T7
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