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SMILES: CC(C)c1cc([nH]n1)C(=O)N1CCC(C1)c1ccc(N)cn1

InChI Key: InChIKey=JUXVBFHULQYYDK-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 281164   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Lysine-specific demethylase 5A


(Homo sapiens (Human))		BDBM281164
PNG
(US10022354, Example 104)
Show SMILES CC(C)c1cc([nH]n1)C(=O)N1CCC(C1)c1ccc(N)cn1
Show InChI InChI=1S/C16H21N5O/c1-10(2)14-7-15(20-19-14)16(22)21-6-5-11(9-21)13-4-3-12(17)8-18-13/h3-4,7-8,10-11H,5-6,9,17H2,1-2H3,(H,19,20)
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MMDB

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US Patent
n/an/a 3.30n/an/an/an/a7.025



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS INC.

US Patent


Assay Description
Full length KDM5A enzyme was expressed and purified inhouse. Biotin-H3K4me3 peptide was purchased from New England Biolabs. HTRF reagents (containing...

US Patent US10022354 (2018)


BindingDB Entry DOI: 10.7270/Q2PC34F7
More data for this
Ligand-Target Pair