BDBM281732 US10023528, Example 5::US10023528, Example 6::US10259776, Example 6

SMILES: C[C@H]([C@H](C(=O)Nc1cc(ccc1Cl)C(C)(CC(O)=O)C1CCC1)c1ccc(Cl)cc1)C(F)(F)F

InChI Key: InChIKey=BTOVIWFUGBHYGN-JXIZHYLBSA-N

Data: 4 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 281732   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Guanylate cyclase soluble subunit alpha-1 (Homo sapiens (Human))	BDBM281732 (US10023528, Example 5 | US10023528, Example 6 | US...) Show SMILES C[C@H]([C@H](C(=O)Nc1cc(ccc1Cl)C(C)(CC(O)=O)C1CCC1)c1ccc(Cl)cc1)C(F)(F)F |r| Show InChI InChI=1S/C25H26Cl2F3NO3/c1-14(25(28,29)30)22(15-6-9-18(26)10-7-15)23(34)31-20-12-17(8-11-19(20)27)24(2,13-21(32)33)16-4-3-5-16/h6-12,14,16,22H,3-5,13H2,1-2H3,(H,31,34)(H,32,33)/t14-,22+,24?/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	5.20	n/a	n/a	7.5	25
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description To carry out the assay, 29 μl of enzyme solution [0-10 nM soluble guanylate cyclase (prepared according to Hönicka et al, J. Mol. Med. 77, 14-23...				US Patent US10023528 (2018) BindingDB Entry DOI: 10.7270/Q21N834J
					More data for this Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1 (Homo sapiens (Human))	BDBM281732 (US10023528, Example 5 | US10023528, Example 6 | US...) Show SMILES C[C@H]([C@H](C(=O)Nc1cc(ccc1Cl)C(C)(CC(O)=O)C1CCC1)c1ccc(Cl)cc1)C(F)(F)F |r| Show InChI InChI=1S/C25H26Cl2F3NO3/c1-14(25(28,29)30)22(15-6-9-18(26)10-7-15)23(34)31-20-12-17(8-11-19(20)27)24(2,13-21(32)33)16-4-3-5-16/h6-12,14,16,22H,3-5,13H2,1-2H3,(H,31,34)(H,32,33)/t14-,22+,24?/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	56	n/a	n/a	n/a	n/a
Institut de Biologie Structurale					Assay Description Soluble guanylate cyclase (sGC) converts on stimulation GTP into cGMP and pyrophosphate (PPi). PPi is detected with the aid of the assay described be...				J Med Chem 51: 1115-25 (2008) BindingDB Entry DOI: 10.7270/Q27083RX
					More data for this Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1 (Homo sapiens (Human))	BDBM281732 (US10023528, Example 5 | US10023528, Example 6 | US...) Show SMILES C[C@H]([C@H](C(=O)Nc1cc(ccc1Cl)C(C)(CC(O)=O)C1CCC1)c1ccc(Cl)cc1)C(F)(F)F |r| Show InChI InChI=1S/C25H26Cl2F3NO3/c1-14(25(28,29)30)22(15-6-9-18(26)10-7-15)23(34)31-20-12-17(8-11-19(20)27)24(2,13-21(32)33)16-4-3-5-16/h6-12,14,16,22H,3-5,13H2,1-2H3,(H,31,34)(H,32,33)/t14-,22+,24?/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	5.20	n/a	n/a	n/a	n/a
Institut de Biologie Structurale					Assay Description Soluble guanylate cyclase (sGC) converts on stimulation GTP into cGMP and pyrophosphate (PPi). PPi is detected with the aid of the assay described be...				J Med Chem 51: 1115-25 (2008) BindingDB Entry DOI: 10.7270/Q27083RX
					More data for this Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1 (Homo sapiens (Human))	BDBM281732 (US10023528, Example 5 | US10023528, Example 6 | US...) Show SMILES C[C@H]([C@H](C(=O)Nc1cc(ccc1Cl)C(C)(CC(O)=O)C1CCC1)c1ccc(Cl)cc1)C(F)(F)F |r| Show InChI InChI=1S/C25H26Cl2F3NO3/c1-14(25(28,29)30)22(15-6-9-18(26)10-7-15)23(34)31-20-12-17(8-11-19(20)27)24(2,13-21(32)33)16-4-3-5-16/h6-12,14,16,22H,3-5,13H2,1-2H3,(H,31,34)(H,32,33)/t14-,22+,24?/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	56	n/a	n/a	7.5	25
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description To carry out the assay, 29 μl of enzyme solution [0-10 nM soluble guanylate cyclase (prepared according to Hönicka et al, J. Mol. Med. 77, 14-23...				US Patent US10023528 (2018) BindingDB Entry DOI: 10.7270/Q21N834J
					More data for this Ligand-Target Pair