BDBM28181 5-(5,6-dimethoxy-1H-1,3-benzodiazol-1-yl)-3-[(2-acetylphenyl)methoxy]thiophene-2-carboxamide::benzimidazole thiophene analogue, 32

SMILES: COc1cc2ncn(-c3cc(OCc4ccccc4C(C)=O)c(s3)C(N)=O)c2cc1OC

InChI Key: InChIKey=CMFKBVPIQXKAAT-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 28181   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase PLK1 (Homo sapiens (Human))	BDBM28181 (5-(5,6-dimethoxy-1H-1,3-benzodiazol-1-yl)-3-[(2-ac...) Show SMILES COc1cc2ncn(-c3cc(OCc4ccccc4C(C)=O)c(s3)C(N)=O)c2cc1OC Show InChI InChI=1S/C23H21N3O5S/c1-13(27)15-7-5-4-6-14(15)11-31-20-10-21(32-22(20)23(24)28)26-12-25-16-8-18(29-2)19(30-3)9-17(16)26/h4-10,12H,11H2,1-3H3,(H2,24,28)	PDB MMDB NCI pathway Reactome pathway KEGG B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	17	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description The compound inhibitory activity was determined by incubation with purified PLK enzyme and biotinylated peptide substrate in the presence ATP/[gamma-...				Bioorg Med Chem Lett 19: 1018-21 (2009) Article DOI: 10.1016/j.bmcl.2008.11.041 BindingDB Entry DOI: 10.7270/Q26T0JZX
					More data for this Ligand-Target Pair