null
SMILES: Nc1ncnc2n(CCCO)cc(-c3ccc(CNc4ncc(cc4C(=O)Nc4ccc(F)cc4)C(F)(F)F)cc3)c12
InChI Key: InChIKey=NEFOEPCGKGIOMB-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
3-phosphoinositide-dependent protein kinase 1 [51-359] (Homo sapiens (Human)) | BDBM282442 (2-(4-(4-amino-7-(3- hydroxypropyl)-7H-pyrrolo [2,3...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <100 | n/a | n/a | n/a | n/a | n/a | n/a |
Sunesis Pharmaceuticals, Inc.; Millenium Pharmaceuticals, Inc. US Patent | Assay Description PDK1 (amino acids 51-359) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) were expressed as N-terminally tagged GST fusi... | US Patent US10030016 (2018) BindingDB Entry DOI: 10.7270/Q2S46V16 | |||||||||||
More data for this Ligand-Target Pair |