BDBM28253 1,3,4-oxadiazole substituted naphthyridine, 20::1-(7-{5-[(4-fluorophenyl)methyl]-1,3,4-oxadiazol-2-yl}-8-hydroxy-1,6-naphthyridin-5-yl)-1,3-diazinan-2-one

SMILES: Oc1c(nc(N2CCCNC2=O)c2cccnc12)-c1nnc(Cc2ccc(F)cc2)o1

InChI Key: InChIKey=NQWXLEOIWKLFOX-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 28253   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
HIV-1 Integrase (Human immunodeficiency virus type 1)	BDBM28253 (1,3,4-oxadiazole substituted naphthyridine, 20 | 1...) Show SMILES Oc1c(nc(N2CCCNC2=O)c2cccnc12)-c1nnc(Cc2ccc(F)cc2)o1 Show InChI InChI=1S/C21H17FN6O3/c22-13-6-4-12(5-7-13)11-15-26-27-20(31-15)17-18(29)16-14(3-1-8-23-16)19(25-17)28-10-2-9-24-21(28)30/h1,3-8,29H,2,9-11H2,(H,24,30)	PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	11	n/a	n/a	n/a	n/a	7.2	37
GSK					Assay Description Purified recombinant integrase was first combined in a complex with biotinylated donor DNA- streptavidin-coated SPA beads. The complex was preincubat...				Bioorg Med Chem Lett 19: 1807-10 (2009) Article DOI: 10.1016/j.bmcl.2009.01.089 BindingDB Entry DOI: 10.7270/Q2TH8K1R
					More data for this Ligand-Target Pair