BDBM28254 1,3,4-oxadiazole substituted naphthyridine, 21::2-(7-{5-[(4-fluorophenyl)methyl]-1,3,4-oxadiazol-2-yl}-8-hydroxy-1,6-naphthyridin-5-yl)-1,2-thiazolidine-1,1-dione

SMILES: Oc1c(nc(N2CCCS2(=O)=O)c2cccnc12)-c1nnc(Cc2ccc(F)cc2)o1

InChI Key: InChIKey=DEKYASBIXCFHDO-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 28254   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
HIV-1 Integrase (Human immunodeficiency virus type 1)	BDBM28254 (1,3,4-oxadiazole substituted naphthyridine, 21 | 2...) Show SMILES Oc1c(nc(N2CCCS2(=O)=O)c2cccnc12)-c1nnc(Cc2ccc(F)cc2)o1 Show InChI InChI=1S/C20H16FN5O4S/c21-13-6-4-12(5-7-13)11-15-24-25-20(30-15)17-18(27)16-14(3-1-8-22-16)19(23-17)26-9-2-10-31(26,28)29/h1,3-8,27H,2,9-11H2	PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	8	n/a	n/a	n/a	n/a	7.2	37
GSK					Assay Description Purified recombinant integrase was first combined in a complex with biotinylated donor DNA- streptavidin-coated SPA beads. The complex was preincubat...				Bioorg Med Chem Lett 19: 1807-10 (2009) Article DOI: 10.1016/j.bmcl.2009.01.089 BindingDB Entry DOI: 10.7270/Q2TH8K1R
					More data for this Ligand-Target Pair