BDBM28268 1,3,4-oxadiazole substituted naphthyridine, 36::7-{5-[(4-fluorophenyl)methyl]-1,3,4-oxadiazol-2-yl}-5-(pyrazin-2-yl)-1,6-naphthyridin-8-ol

SMILES: Oc1c(nc(-c2cnccn2)c2cccnc12)-c1nnc(Cc2ccc(F)cc2)o1

InChI Key: InChIKey=HRHATTAFJPWMSS-UHFFFAOYSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 28268   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
HIV-1 Integrase (Human immunodeficiency virus type 1)	BDBM28268 (1,3,4-oxadiazole substituted naphthyridine, 36 | 7...) Show SMILES Oc1c(nc(-c2cnccn2)c2cccnc12)-c1nnc(Cc2ccc(F)cc2)o1 Show InChI InChI=1S/C21H13FN6O2/c22-13-5-3-12(4-6-13)10-16-27-28-21(30-16)19-20(29)18-14(2-1-7-25-18)17(26-19)15-11-23-8-9-24-15/h1-9,11,29H,10H2	PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description Purified recombinant integrase was first combined in a complex with biotinylated donor DNA- streptavidin-coated SPA beads. The complex was preincubat...				Bioorg Med Chem Lett 19: 1807-10 (2009) Article DOI: 10.1016/j.bmcl.2009.01.089 BindingDB Entry DOI: 10.7270/Q2TH8K1R
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