BDBM28278 1,3,4-oxadiazole substituted naphthyridine, 46::4-(7-{5-[(4-fluorophenyl)methyl]-1,3,4-oxadiazol-2-yl}-8-hydroxy-1,6-naphthyridin-5-yl)-N-(propan-2-yl)benzamide

SMILES: CC(C)NC(=O)c1ccc(cc1)-c1nc(-c2nnc(Cc3ccc(F)cc3)o2)c(O)c2ncccc12

InChI Key: InChIKey=UVMMYYFIVCXCTA-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 28278   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
HIV-1 Integrase (Human immunodeficiency virus type 1)	BDBM28278 (1,3,4-oxadiazole substituted naphthyridine, 46 | 4...) Show SMILES CC(C)NC(=O)c1ccc(cc1)-c1nc(-c2nnc(Cc3ccc(F)cc3)o2)c(O)c2ncccc12 Show InChI InChI=1S/C27H22FN5O3/c1-15(2)30-26(35)18-9-7-17(8-10-18)22-20-4-3-13-29-23(20)25(34)24(31-22)27-33-32-21(36-27)14-16-5-11-19(28)12-6-16/h3-13,15,34H,14H2,1-2H3,(H,30,35)	PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description Purified recombinant integrase was first combined in a complex with biotinylated donor DNA- streptavidin-coated SPA beads. The complex was preincubat...				Bioorg Med Chem Lett 19: 1807-10 (2009) Article DOI: 10.1016/j.bmcl.2009.01.089 BindingDB Entry DOI: 10.7270/Q2TH8K1R
					More data for this Ligand-Target Pair