BDBM28287 1,3,4-oxadiazole substituted naphthyridine, 55::7-{5-[(4-fluorophenyl)methyl]-1,3,4-oxadiazol-2-yl}-5-(3-methanesulfonylphenyl)-1,6-naphthyridin-8-ol

SMILES: CS(=O)(=O)c1cccc(c1)-c1nc(-c2nnc(Cc3ccc(F)cc3)o2)c(O)c2ncccc12

InChI Key: InChIKey=PGEHXNGNDFMCRL-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 28287   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
HIV-1 Integrase (Human immunodeficiency virus type 1)	BDBM28287 (1,3,4-oxadiazole substituted naphthyridine, 55 | 7...) Show SMILES CS(=O)(=O)c1cccc(c1)-c1nc(-c2nnc(Cc3ccc(F)cc3)o2)c(O)c2ncccc12 Show InChI InChI=1S/C24H17FN4O4S/c1-34(31,32)17-5-2-4-15(13-17)20-18-6-3-11-26-21(18)23(30)22(27-20)24-29-28-19(33-24)12-14-7-9-16(25)10-8-14/h2-11,13,30H,12H2,1H3	PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description Purified recombinant integrase was first combined in a complex with biotinylated donor DNA- streptavidin-coated SPA beads. The complex was preincubat...				Bioorg Med Chem Lett 19: 1807-10 (2009) Article DOI: 10.1016/j.bmcl.2009.01.089 BindingDB Entry DOI: 10.7270/Q2TH8K1R
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