BDBM283354 N-((1-aminoisoquinolin-6-yl)methyl)-2-((3- cyanoquinolin-6-yl)methyl)isonicotinamide::US10023557, Example 6::US10266515, Example 6::US10308637, Example 6::US9611252, Example 6
SMILES: Nc1nccc2cc(CNC(=O)c3ccnc(Cc4ccc5ncc(cc5c4)C#N)c3)ccc12
InChI Key: InChIKey=KYRAMUYNXMHHJI-UHFFFAOYSA-N
Data: 5 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Plasma kallikrein (Homo sapiens (Human)) | BDBM283354 (N-((1-aminoisoquinolin-6-yl)methyl)-2-((3- cyanoqu...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <100 | n/a | n/a | n/a | n/a | 7.5 | n/a |
LIFESCI PHARMACEUTICALS, INC. US Patent | Assay Description A 10 mM solution of the test compound was made in DMSO. This solution was serially diluted 1:5 in DMSO to yield 2000, 400, 80, 16, 3.2, 0.64, 0.128, ... | US Patent US10023557 (2018) BindingDB Entry DOI: 10.7270/Q2BZ6839 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Plasma kallikrein (Homo sapiens (Human)) | BDBM283354 (N-((1-aminoisoquinolin-6-yl)methyl)-2-((3- cyanoqu...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <100 | n/a | n/a | n/a | n/a | n/a | n/a |
LIFESCI PHARMACEUTICALS, INC. US Patent | Assay Description The ability of the compounds disclosed herein to inhibit human plasma kallikrein activity was quantified according to the procedures below.A 10 mM so... | US Patent US9611252 (2017) BindingDB Entry DOI: 10.7270/Q2930W8S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Plasma kallikrein (Homo sapiens (Human)) | BDBM283354 (N-((1-aminoisoquinolin-6-yl)methyl)-2-((3- cyanoqu...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <100 | n/a | n/a | n/a | n/a | n/a | n/a |
ATTUNE PHARMACEUTICALS, INC. US Patent | Assay Description A 10 mM solution of the test compound was made in DMSO. This solution was serially diluted 1:5 in DMSO to yield 2000, 400, 80, 16, 3.2, 0.64, 0.128, ... | US Patent US11021463 (2021) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Plasma kallikrein (Homo sapiens (Human)) | BDBM283354 (N-((1-aminoisoquinolin-6-yl)methyl)-2-((3- cyanoqu...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <100 | n/a | n/a | n/a | n/a | n/a | n/a |
ENSCMu | Assay Description A 10 mM solution of the test compound was made in DMSO. This solution was serially diluted 1:5 in DMSO to yield 2000, 400, 80, 16, 3.2, 0.64, 0.128, ... | Bioorg Med Chem 14: 7241-57 (2006) BindingDB Entry DOI: 10.7270/Q2J968P7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase kinase kinase kinase 1 (Homo sapiens (Human)) | BDBM283354 (N-((1-aminoisoquinolin-6-yl)methyl)-2-((3- cyanoqu...) | PDB NCI pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <100 | n/a | n/a | n/a | n/a | n/a | n/a |
Vitae Pharmaceuticals | Assay Description A 10 mM solution of the test compound was made in DMSO. This solution was serially diluted 1:5 in DMSO to yield 2000, 400, 80, 16, 3.2, 0.64, 0.128, ... | Bioorg Med Chem Lett 19: 3541-5 (2009) BindingDB Entry DOI: 10.7270/Q25141K2 | |||||||||||
More data for this Ligand-Target Pair |