BDBM285497 4-[4-Cyano-2-({[(2′R,4S)-6-(5-fluoro-2-pyridinyl)-2,3-dihydrospiro[chromene-4,1′-cyclopropan]-2′-yl]carbonyl}amino)phenyl]butanoic acid::US10077247, Example 10-9
SMILES: OC(=O)CCCc1ccc(cc1NC(=O)[C@@H]1C[C@]11CCOc2ccc(cc12)-c1ccc(F)cn1)C#N
InChI Key: InChIKey=IWRXMIGQVJNTAE-DWACAAAGSA-N
Data: 1 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Prostaglandin E2 receptor EP4 subtype (Homo sapiens (Human)) | BDBM285497![]() (4-[4-Cyano-2-({[(2′R,4S)-6-(5-fluoro-2-pyrid...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 6.70 | n/a | n/a | n/a | n/a | n/a | 25 |
ONO PHARMACEUTICAL CO., LTD. US Patent | Assay Description EP4 Antagonistic Activity Measurement Experiment Using Prostanoid Receptor Subtype Expressing CellsCHO cells expressing rat EP4 receptor subtypes wer... | US Patent US10077247 (2018) BindingDB Entry DOI: 10.7270/Q22J6DWN | |||||||||||
More data for this Ligand-Target Pair |