BDBM285511 4-[4-Cyano-2-({[(1S,2R)-6′-[(2-methoxyethyl)carbamoyl]-3′,3′-dimethyl-2′,3′-dihydrospiro[cyclopropane-1, 1′-inden]-2-yl]carbonyl}amino)phenyl]butanoic acid::US10077247, Example 38-1
SMILES: COCCNC(=O)c1ccc2c(c1)[C@@]1(C[C@H]1C(=O)Nc1cc(ccc1CCCC(O)=O)C#N)CC2(C)C
InChI Key: InChIKey=PCCVEUAPMPIIHS-MUAVYFROSA-N
Data: 1 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Prostaglandin E2 receptor EP4 subtype (Homo sapiens (Human)) | BDBM285511![]() (4-[4-Cyano-2-({[(1S,2R)-6′-[(2-methoxyethyl)...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 5.40 | n/a | n/a | n/a | n/a | n/a | 25 |
ONO PHARMACEUTICAL CO., LTD. US Patent | Assay Description EP4 Antagonistic Activity Measurement Experiment Using Prostanoid Receptor Subtype Expressing CellsCHO cells expressing rat EP4 receptor subtypes wer... | US Patent US10077247 (2018) BindingDB Entry DOI: 10.7270/Q22J6DWN | |||||||||||
More data for this Ligand-Target Pair |