BDBM286240 4-(3-cyclopropyl-8- fluoroimidazo[1,2-a]pyridin-2- yl)isoquinoline::US9518055, Example 44

SMILES: Fc1cccn2c(C3CC3)c(nc12)-c1cncc2ccccc12

InChI Key: InChIKey=JKSXZWXLFVIZOH-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 286240   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cytochrome P450 11B1, mitochondrial (Homo sapiens (Human))	BDBM286240 (4-(3-cyclopropyl-8- fluoroimidazo[1,2-a]pyridin-2-...) Show SMILES Fc1cccn2c(C3CC3)c(nc12)-c1cncc2ccccc12 Show InChI InChI=1S/C19H14FN3/c20-16-6-3-9-23-18(12-7-8-12)17(22-19(16)23)15-11-21-10-13-4-1-2-5-14(13)15/h1-6,9-12H,7-8H2	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.19E+3	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme US Patent					Assay Description V79 cell lines stably expressing the either the human CYP11B2 or the human CYP11B1 enzyme were generated using a standard transfection protocol. V79 ...				US Patent US9518055 (2016) BindingDB Entry DOI: 10.7270/Q23B625B
					More data for this Ligand-Target Pair
Cytochrome P450 11B2 (CYP11B2) (Homo sapiens (Human))	BDBM286240 (4-(3-cyclopropyl-8- fluoroimidazo[1,2-a]pyridin-2-...) Show SMILES Fc1cccn2c(C3CC3)c(nc12)-c1cncc2ccccc12 Show InChI InChI=1S/C19H14FN3/c20-16-6-3-9-23-18(12-7-8-12)17(22-19(16)23)15-11-21-10-13-4-1-2-5-14(13)15/h1-6,9-12H,7-8H2	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	14.5	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme US Patent					Assay Description V79 cell lines stably expressing the either the human CYP11B2 or the human CYP11B1 enzyme were generated using a standard transfection protocol. V79 ...				US Patent US9518055 (2016) BindingDB Entry DOI: 10.7270/Q23B625B
					More data for this Ligand-Target Pair