BDBM287022 (8-(3-(4-acryloylpiperazin-1-yl)propyl)-6-(2,6-dichloro-3,5-dimethoxyphenyl)-2-((1,3-dimethoxypropan-2-yl)amino)pyrido[2,3-d]pyrimidin-7(8H)-one::US10294223, Cpd No. 57::US9567334, Example 57::US9815834, Compound 57

SMILES: COCC(COC)Nc1ncc2cc(-c3c(Cl)c(OC)cc(OC)c3Cl)c(=O)n(CCCN3CCN(CC3)C(=O)C=C)c2n1

InChI Key: InChIKey=KCIGGSIEQASIPY-UHFFFAOYSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 287022   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM287022 ((8-(3-(4-acryloylpiperazin-1-yl)propyl)-6-(2,6-dic...) Show SMILES COCC(COC)Nc1ncc2cc(-c3c(Cl)c(OC)cc(OC)c3Cl)c(=O)n(CCCN3CCN(CC3)C(=O)C=C)c2n1 |(-8,-3.85,;-6.67,-3.08,;-6.67,-1.54,;-5.33,-.77,;-4,-1.54,;-4,-3.08,;-2.67,-3.85,;-5.33,.77,;-4,1.54,;-4,3.08,;-2.67,3.85,;-1.33,3.08,;,3.85,;1.33,3.08,;2.67,3.85,;2.67,5.39,;1.33,6.16,;4,6.16,;4,7.7,;2.67,8.47,;5.33,5.39,;5.33,3.85,;6.67,3.08,;8,3.85,;4,3.08,;4,1.54,;1.33,1.54,;2.67,.77,;,.77,;,-.77,;1.33,-1.54,;1.33,-3.08,;2.67,-3.85,;2.67,-5.39,;4,-6.16,;5.33,-5.39,;5.33,-3.85,;4,-3.08,;6.67,-6.16,;8,-5.39,;6.67,-7.7,;8,-8.47,;-1.33,1.54,;-2.67,.77,)| Show InChI InChI=1S/C30H38Cl2N6O6/c1-6-24(39)37-12-10-36(11-13-37)8-7-9-38-28-19(16-33-30(35-28)34-20(17-41-2)18-42-3)14-21(29(38)40)25-26(31)22(43-4)15-23(44-5)27(25)32/h6,14-16,20H,1,7-13,17-18H2,2-5H3,(H,33,34,35)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.40	n/a	n/a	n/a	n/a	n/a	25
Principia Biopharma, Inc. US Patent					Assay Description A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...				US Patent US9567334 (2017) BindingDB Entry DOI: 10.7270/Q2XK8HKQ
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM287022 ((8-(3-(4-acryloylpiperazin-1-yl)propyl)-6-(2,6-dic...) Show SMILES COCC(COC)Nc1ncc2cc(-c3c(Cl)c(OC)cc(OC)c3Cl)c(=O)n(CCCN3CCN(CC3)C(=O)C=C)c2n1 |(-8,-3.85,;-6.67,-3.08,;-6.67,-1.54,;-5.33,-.77,;-4,-1.54,;-4,-3.08,;-2.67,-3.85,;-5.33,.77,;-4,1.54,;-4,3.08,;-2.67,3.85,;-1.33,3.08,;,3.85,;1.33,3.08,;2.67,3.85,;2.67,5.39,;1.33,6.16,;4,6.16,;4,7.7,;2.67,8.47,;5.33,5.39,;5.33,3.85,;6.67,3.08,;8,3.85,;4,3.08,;4,1.54,;1.33,1.54,;2.67,.77,;,.77,;,-.77,;1.33,-1.54,;1.33,-3.08,;2.67,-3.85,;2.67,-5.39,;4,-6.16,;5.33,-5.39,;5.33,-3.85,;4,-3.08,;6.67,-6.16,;8,-5.39,;6.67,-7.7,;8,-8.47,;-1.33,1.54,;-2.67,.77,)| Show InChI InChI=1S/C30H38Cl2N6O6/c1-6-24(39)37-12-10-36(11-13-37)8-7-9-38-28-19(16-33-30(35-28)34-20(17-41-2)18-42-3)14-21(29(38)40)25-26(31)22(43-4)15-23(44-5)27(25)32/h6,14-16,20H,1,7-13,17-18H2,2-5H3,(H,33,34,35)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.40	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim Pharmaceuticals Inc.					Assay Description A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...				Bioorg Med Chem Lett 19: 773-7 (2009) BindingDB Entry DOI: 10.7270/Q2GX4DVZ
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	US11078199, Cpd 57 ((8-(3-(4-acryloylpiperazin-1-yl)propyl)-6-(2,6-dic...) Show SMILES COCC(COC)Nc1ncc2cc(-c3c(Cl)c(OC)cc(OC)c3Cl)c(=O)n(CCCN3CCN(CC3)C(=O)C=C)c2n1 |(-8,-3.85,;-6.67,-3.08,;-6.67,-1.54,;-5.33,-.77,;-4,-1.54,;-4,-3.08,;-2.67,-3.85,;-5.33,.77,;-4,1.54,;-4,3.08,;-2.67,3.85,;-1.33,3.08,;,3.85,;1.33,3.08,;2.67,3.85,;2.67,5.39,;1.33,6.16,;4,6.16,;4,7.7,;2.67,8.47,;5.33,5.39,;5.33,3.85,;6.67,3.08,;8,3.85,;4,3.08,;4,1.54,;1.33,1.54,;2.67,.77,;,.77,;,-.77,;1.33,-1.54,;1.33,-3.08,;2.67,-3.85,;2.67,-5.39,;4,-6.16,;5.33,-5.39,;5.33,-3.85,;4,-3.08,;6.67,-6.16,;8,-5.39,;6.67,-7.7,;8,-8.47,;-1.33,1.54,;-2.67,.77,)| Show InChI InChI=1S/C30H38Cl2N6O6/c1-6-24(39)37-12-10-36(11-13-37)8-7-9-38-28-19(16-33-30(35-28)34-20(17-41-2)18-42-3)14-21(29(38)40)25-26(31)22(43-4)15-23(44-5)27(25)32/h6,14-16,20H,1,7-13,17-18H2,2-5H3,(H,33,34,35)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	1.40	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM287022 ((8-(3-(4-acryloylpiperazin-1-yl)propyl)-6-(2,6-dic...) Show SMILES COCC(COC)Nc1ncc2cc(-c3c(Cl)c(OC)cc(OC)c3Cl)c(=O)n(CCCN3CCN(CC3)C(=O)C=C)c2n1 |(-8,-3.85,;-6.67,-3.08,;-6.67,-1.54,;-5.33,-.77,;-4,-1.54,;-4,-3.08,;-2.67,-3.85,;-5.33,.77,;-4,1.54,;-4,3.08,;-2.67,3.85,;-1.33,3.08,;,3.85,;1.33,3.08,;2.67,3.85,;2.67,5.39,;1.33,6.16,;4,6.16,;4,7.7,;2.67,8.47,;5.33,5.39,;5.33,3.85,;6.67,3.08,;8,3.85,;4,3.08,;4,1.54,;1.33,1.54,;2.67,.77,;,.77,;,-.77,;1.33,-1.54,;1.33,-3.08,;2.67,-3.85,;2.67,-5.39,;4,-6.16,;5.33,-5.39,;5.33,-3.85,;4,-3.08,;6.67,-6.16,;8,-5.39,;6.67,-7.7,;8,-8.47,;-1.33,1.54,;-2.67,.77,)| Show InChI InChI=1S/C30H38Cl2N6O6/c1-6-24(39)37-12-10-36(11-13-37)8-7-9-38-28-19(16-33-30(35-28)34-20(17-41-2)18-42-3)14-21(29(38)40)25-26(31)22(43-4)15-23(44-5)27(25)32/h6,14-16,20H,1,7-13,17-18H2,2-5H3,(H,33,34,35)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	12.8	n/a	n/a	n/a	n/a	n/a	n/a
PRINCIPIA BIOPHARMA, INC. US Patent					Assay Description A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...				US Patent US9815834 (2017) BindingDB Entry DOI: 10.7270/Q2B85B83
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 2 (Homo sapiens (Human))	BDBM287022 ((8-(3-(4-acryloylpiperazin-1-yl)propyl)-6-(2,6-dic...) Show SMILES COCC(COC)Nc1ncc2cc(-c3c(Cl)c(OC)cc(OC)c3Cl)c(=O)n(CCCN3CCN(CC3)C(=O)C=C)c2n1 |(-8,-3.85,;-6.67,-3.08,;-6.67,-1.54,;-5.33,-.77,;-4,-1.54,;-4,-3.08,;-2.67,-3.85,;-5.33,.77,;-4,1.54,;-4,3.08,;-2.67,3.85,;-1.33,3.08,;,3.85,;1.33,3.08,;2.67,3.85,;2.67,5.39,;1.33,6.16,;4,6.16,;4,7.7,;2.67,8.47,;5.33,5.39,;5.33,3.85,;6.67,3.08,;8,3.85,;4,3.08,;4,1.54,;1.33,1.54,;2.67,.77,;,.77,;,-.77,;1.33,-1.54,;1.33,-3.08,;2.67,-3.85,;2.67,-5.39,;4,-6.16,;5.33,-5.39,;5.33,-3.85,;4,-3.08,;6.67,-6.16,;8,-5.39,;6.67,-7.7,;8,-8.47,;-1.33,1.54,;-2.67,.77,)| Show InChI InChI=1S/C30H38Cl2N6O6/c1-6-24(39)37-12-10-36(11-13-37)8-7-9-38-28-19(16-33-30(35-28)34-20(17-41-2)18-42-3)14-21(29(38)40)25-26(31)22(43-4)15-23(44-5)27(25)32/h6,14-16,20H,1,7-13,17-18H2,2-5H3,(H,33,34,35)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	12.8	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim Pharmaceuticals Inc.					Assay Description The cell-based effects of FGFR inhibitors were determined by measuring inhibition of FGFR-dependent cell line growth. The cell lines SNU-16 was used ...				Bioorg Med Chem Lett 19: 773-7 (2009) BindingDB Entry DOI: 10.7270/Q2GX4DVZ
					More data for this Ligand-Target Pair