null

SMILES: CNc1ncc2cc(-c3cc(OC)cc(OC)c3Cl)c(=O)n(CCOC3CN(C3)C(=O)C=C)c2n1

InChI Key: InChIKey=GVEQLTBABUNRMS-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 287037   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM287037 (8-(2-((1-acryloylazetidin-3-yl)oxy)ethyl)-6-(2-chl...) Show SMILES CNc1ncc2cc(-c3cc(OC)cc(OC)c3Cl)c(=O)n(CCOC3CN(C3)C(=O)C=C)c2n1 Show InChI InChI=1S/C24H26ClN5O5/c1-5-20(31)29-12-16(13-29)35-7-6-30-22-14(11-27-24(26-2)28-22)8-18(23(30)32)17-9-15(33-3)10-19(34-4)21(17)25/h5,8-11,16H,1,6-7,12-13H2,2-4H3,(H,26,27,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.70	n/a	n/a	n/a	n/a	n/a	25
Principia Biopharma, Inc. US Patent					Assay Description A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...				US Patent US9567334 (2017) BindingDB Entry DOI: 10.7270/Q2XK8HKQ
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM287037 (8-(2-((1-acryloylazetidin-3-yl)oxy)ethyl)-6-(2-chl...) Show SMILES CNc1ncc2cc(-c3cc(OC)cc(OC)c3Cl)c(=O)n(CCOC3CN(C3)C(=O)C=C)c2n1 Show InChI InChI=1S/C24H26ClN5O5/c1-5-20(31)29-12-16(13-29)35-7-6-30-22-14(11-27-24(26-2)28-22)8-18(23(30)32)17-9-15(33-3)10-19(34-4)21(17)25/h5,8-11,16H,1,6-7,12-13H2,2-4H3,(H,26,27,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	1.70	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM287037 (8-(2-((1-acryloylazetidin-3-yl)oxy)ethyl)-6-(2-chl...) Show SMILES CNc1ncc2cc(-c3cc(OC)cc(OC)c3Cl)c(=O)n(CCOC3CN(C3)C(=O)C=C)c2n1 Show InChI InChI=1S/C24H26ClN5O5/c1-5-20(31)29-12-16(13-29)35-7-6-30-22-14(11-27-24(26-2)28-22)8-18(23(30)32)17-9-15(33-3)10-19(34-4)21(17)25/h5,8-11,16H,1,6-7,12-13H2,2-4H3,(H,26,27,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.40	n/a	n/a	n/a	n/a	n/a	n/a
PRINCIPIA BIOPHARMA, INC. US Patent					Assay Description A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...				US Patent US9815834 (2017) BindingDB Entry DOI: 10.7270/Q2B85B83
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 2 (Homo sapiens (Human))	BDBM287037 (8-(2-((1-acryloylazetidin-3-yl)oxy)ethyl)-6-(2-chl...) Show SMILES CNc1ncc2cc(-c3cc(OC)cc(OC)c3Cl)c(=O)n(CCOC3CN(C3)C(=O)C=C)c2n1 Show InChI InChI=1S/C24H26ClN5O5/c1-5-20(31)29-12-16(13-29)35-7-6-30-22-14(11-27-24(26-2)28-22)8-18(23(30)32)17-9-15(33-3)10-19(34-4)21(17)25/h5,8-11,16H,1,6-7,12-13H2,2-4H3,(H,26,27,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.40	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim Pharmaceuticals Inc.					Assay Description The cell-based effects of FGFR inhibitors were determined by measuring inhibition of FGFR-dependent cell line growth. The cell lines SNU-16 was used ...				Bioorg Med Chem Lett 19: 773-7 (2009) BindingDB Entry DOI: 10.7270/Q2GX4DVZ
					More data for this Ligand-Target Pair