null

SMILES: COc1cc(OC)c(Cl)c(c1)-c1cc2cnc(N[C@H]3CCOC3)nc2n(CCCN2CCN(CC2)C(=O)C=C)c1=O

InChI Key: InChIKey=XFGMNTTVFYLJIS-FQEVSTJZSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 287061   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM287061 ((S)-8-(3-(4-acryloylpiperazin-1-yl)propyl)-6-(2-ch...) Show SMILES COc1cc(OC)c(Cl)c(c1)-c1cc2cnc(N[C@H]3CCOC3)nc2n(CCCN2CCN(CC2)C(=O)C=C)c1=O |r| Show InChI InChI=1S/C29H35ClN6O5/c1-4-25(37)35-11-9-34(10-12-35)7-5-8-36-27-19(17-31-29(33-27)32-20-6-13-41-18-20)14-23(28(36)38)22-15-21(39-2)16-24(40-3)26(22)30/h4,14-17,20H,1,5-13,18H2,2-3H3,(H,31,32,33)/t20-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.60	n/a	n/a	n/a	n/a	n/a	25
Principia Biopharma, Inc. US Patent					Assay Description A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...				US Patent US9567334 (2017) BindingDB Entry DOI: 10.7270/Q2XK8HKQ
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM287061 ((S)-8-(3-(4-acryloylpiperazin-1-yl)propyl)-6-(2-ch...) Show SMILES COc1cc(OC)c(Cl)c(c1)-c1cc2cnc(N[C@H]3CCOC3)nc2n(CCCN2CCN(CC2)C(=O)C=C)c1=O |r| Show InChI InChI=1S/C29H35ClN6O5/c1-4-25(37)35-11-9-34(10-12-35)7-5-8-36-27-19(17-31-29(33-27)32-20-6-13-41-18-20)14-23(28(36)38)22-15-21(39-2)16-24(40-3)26(22)30/h4,14-17,20H,1,5-13,18H2,2-3H3,(H,31,32,33)/t20-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.60	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim Pharmaceuticals Inc.					Assay Description A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...				Bioorg Med Chem Lett 19: 773-7 (2009) BindingDB Entry DOI: 10.7270/Q2GX4DVZ
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM287061 ((S)-8-(3-(4-acryloylpiperazin-1-yl)propyl)-6-(2-ch...) Show SMILES COc1cc(OC)c(Cl)c(c1)-c1cc2cnc(N[C@H]3CCOC3)nc2n(CCCN2CCN(CC2)C(=O)C=C)c1=O |r| Show InChI InChI=1S/C29H35ClN6O5/c1-4-25(37)35-11-9-34(10-12-35)7-5-8-36-27-19(17-31-29(33-27)32-20-6-13-41-18-20)14-23(28(36)38)22-15-21(39-2)16-24(40-3)26(22)30/h4,14-17,20H,1,5-13,18H2,2-3H3,(H,31,32,33)/t20-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	1.60	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM287061 ((S)-8-(3-(4-acryloylpiperazin-1-yl)propyl)-6-(2-ch...) Show SMILES COc1cc(OC)c(Cl)c(c1)-c1cc2cnc(N[C@H]3CCOC3)nc2n(CCCN2CCN(CC2)C(=O)C=C)c1=O |r| Show InChI InChI=1S/C29H35ClN6O5/c1-4-25(37)35-11-9-34(10-12-35)7-5-8-36-27-19(17-31-29(33-27)32-20-6-13-41-18-20)14-23(28(36)38)22-15-21(39-2)16-24(40-3)26(22)30/h4,14-17,20H,1,5-13,18H2,2-3H3,(H,31,32,33)/t20-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
PRINCIPIA BIOPHARMA, INC. US Patent					Assay Description A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...				US Patent US9815834 (2017) BindingDB Entry DOI: 10.7270/Q2B85B83
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 2 (Homo sapiens (Human))	BDBM287061 ((S)-8-(3-(4-acryloylpiperazin-1-yl)propyl)-6-(2-ch...) Show SMILES COc1cc(OC)c(Cl)c(c1)-c1cc2cnc(N[C@H]3CCOC3)nc2n(CCCN2CCN(CC2)C(=O)C=C)c1=O |r| Show InChI InChI=1S/C29H35ClN6O5/c1-4-25(37)35-11-9-34(10-12-35)7-5-8-36-27-19(17-31-29(33-27)32-20-6-13-41-18-20)14-23(28(36)38)22-15-21(39-2)16-24(40-3)26(22)30/h4,14-17,20H,1,5-13,18H2,2-3H3,(H,31,32,33)/t20-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim Pharmaceuticals Inc.					Assay Description The cell-based effects of FGFR inhibitors were determined by measuring inhibition of FGFR-dependent cell line growth. The cell lines SNU-16 was used ...				Bioorg Med Chem Lett 19: 773-7 (2009) BindingDB Entry DOI: 10.7270/Q2GX4DVZ
					More data for this Ligand-Target Pair