null

SMILES: COc1cc(OC)c(Cl)c(c1Cl)-c1cc2cnc(NC(C)C)nc2n(CCN(C)C2CCN(CC2)C(=O)C=C)c1=O

InChI Key: InChIKey=XCVNJBNNYAALER-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 287080   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM287080 (8-(2-((1-acryloylpiperidin-4-yl)(methyl)amino)ethy...) Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1cc2cnc(NC(C)C)nc2n(CCN(C)C2CCN(CC2)C(=O)C=C)c1=O |(4,8.09,;2.67,7.32,;2.67,5.78,;4,5,;4,3.46,;5.33,2.69,;6.67,3.46,;2.67,2.69,;2.67,1.15,;1.33,3.46,;1.33,5,;,5.77,;,2.69,;-1.33,3.46,;-2.67,2.69,;-4,3.46,;-5.33,2.69,;-5.33,1.15,;-6.67,.38,;-6.67,-1.16,;-8,-1.93,;-5.33,-1.93,;-4,.38,;-2.67,1.15,;-1.33,.38,;-1.33,-1.16,;,-1.93,;,-3.47,;-1.33,-4.24,;1.33,-4.24,;1.33,-5.78,;2.67,-6.55,;4,-5.78,;4,-4.24,;2.67,-3.47,;5.33,-6.55,;5.33,-8.09,;6.67,-5.78,;8,-6.55,;,1.15,;1.33,.38,)| Show InChI InChI=1S/C29H36Cl2N6O4/c1-7-23(38)36-10-8-19(9-11-36)35(4)12-13-37-27-18(16-32-29(34-27)33-17(2)3)14-20(28(37)39)24-25(30)21(40-5)15-22(41-6)26(24)31/h7,14-17,19H,1,8-13H2,2-6H3,(H,32,33,34)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	1.30	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM287080 (8-(2-((1-acryloylpiperidin-4-yl)(methyl)amino)ethy...) Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1cc2cnc(NC(C)C)nc2n(CCN(C)C2CCN(CC2)C(=O)C=C)c1=O |(4,8.09,;2.67,7.32,;2.67,5.78,;4,5,;4,3.46,;5.33,2.69,;6.67,3.46,;2.67,2.69,;2.67,1.15,;1.33,3.46,;1.33,5,;,5.77,;,2.69,;-1.33,3.46,;-2.67,2.69,;-4,3.46,;-5.33,2.69,;-5.33,1.15,;-6.67,.38,;-6.67,-1.16,;-8,-1.93,;-5.33,-1.93,;-4,.38,;-2.67,1.15,;-1.33,.38,;-1.33,-1.16,;,-1.93,;,-3.47,;-1.33,-4.24,;1.33,-4.24,;1.33,-5.78,;2.67,-6.55,;4,-5.78,;4,-4.24,;2.67,-3.47,;5.33,-6.55,;5.33,-8.09,;6.67,-5.78,;8,-6.55,;,1.15,;1.33,.38,)| Show InChI InChI=1S/C29H36Cl2N6O4/c1-7-23(38)36-10-8-19(9-11-36)35(4)12-13-37-27-18(16-32-29(34-27)33-17(2)3)14-20(28(37)39)24-25(30)21(40-5)15-22(41-6)26(24)31/h7,14-17,19H,1,8-13H2,2-6H3,(H,32,33,34)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.30	n/a	n/a	n/a	n/a	n/a	25
Principia Biopharma, Inc. US Patent					Assay Description A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...				US Patent US9567334 (2017) BindingDB Entry DOI: 10.7270/Q2XK8HKQ
					More data for this Ligand-Target Pair