BDBM287555 8-(2-((1-acryloylazetidin-3-yl)oxy)ethyl)-6-(2,6-dichloro-3,5-dimethoxyphenyl)-2-((4-(diethylamino)butyl)amino)pyrido[2,3-d]pyrimidin-7(8H)-one::US10294223, Cpd No. 103::US9567334, Example 103::US9815834, Compound 103

SMILES: CCN(CC)CCCCNc1ncc2cc(-c3c(Cl)c(OC)cc(OC)c3Cl)c(=O)n(CCOC3CN(C3)C(=O)C=C)c2n1

InChI Key: InChIKey=MBFNJGNWXZAXKI-UHFFFAOYSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 287555   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM287555 (8-(2-((1-acryloylazetidin-3-yl)oxy)ethyl)-6-(2,6-d...) Show SMILES CCN(CC)CCCCNc1ncc2cc(-c3c(Cl)c(OC)cc(OC)c3Cl)c(=O)n(CCOC3CN(C3)C(=O)C=C)c2n1 |(-8.95,-8.09,;-8.95,-6.55,;-7.61,-5.78,;-6.28,-6.55,;-6.28,-8.09,;-7.61,-4.24,;-6.28,-3.47,;-6.28,-1.93,;-4.94,-1.16,;-4.94,.38,;-3.61,1.15,;-3.61,2.69,;-2.28,3.46,;-.94,2.69,;.39,3.46,;1.72,2.69,;3.06,3.46,;3.06,5,;1.72,5.77,;4.39,5.78,;4.39,7.32,;5.73,8.09,;5.73,5,;5.73,3.46,;7.06,2.69,;8.39,3.46,;4.39,2.69,;4.39,1.15,;1.72,1.15,;3.06,.38,;.39,.38,;.39,-1.16,;1.72,-1.93,;1.72,-3.47,;3.06,-4.24,;3.46,-5.72,;4.94,-5.32,;4.55,-3.84,;6.28,-6.09,;6.28,-7.63,;7.61,-5.32,;8.95,-6.09,;-.94,1.15,;-2.28,.38,)| Show InChI InChI=1S/C31H40Cl2N6O5/c1-6-25(40)38-18-21(19-38)44-14-13-39-29-20(17-35-31(36-29)34-11-9-10-12-37(7-2)8-3)15-22(30(39)41)26-27(32)23(42-4)16-24(43-5)28(26)33/h6,15-17,21H,1,7-14,18-19H2,2-5H3,(H,34,35,36)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.5	n/a	n/a	n/a	n/a	n/a	25
Principia Biopharma, Inc. US Patent					Assay Description A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...				US Patent US9567334 (2017) BindingDB Entry DOI: 10.7270/Q2XK8HKQ
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM287555 (8-(2-((1-acryloylazetidin-3-yl)oxy)ethyl)-6-(2,6-d...) Show SMILES CCN(CC)CCCCNc1ncc2cc(-c3c(Cl)c(OC)cc(OC)c3Cl)c(=O)n(CCOC3CN(C3)C(=O)C=C)c2n1 |(-8.95,-8.09,;-8.95,-6.55,;-7.61,-5.78,;-6.28,-6.55,;-6.28,-8.09,;-7.61,-4.24,;-6.28,-3.47,;-6.28,-1.93,;-4.94,-1.16,;-4.94,.38,;-3.61,1.15,;-3.61,2.69,;-2.28,3.46,;-.94,2.69,;.39,3.46,;1.72,2.69,;3.06,3.46,;3.06,5,;1.72,5.77,;4.39,5.78,;4.39,7.32,;5.73,8.09,;5.73,5,;5.73,3.46,;7.06,2.69,;8.39,3.46,;4.39,2.69,;4.39,1.15,;1.72,1.15,;3.06,.38,;.39,.38,;.39,-1.16,;1.72,-1.93,;1.72,-3.47,;3.06,-4.24,;3.46,-5.72,;4.94,-5.32,;4.55,-3.84,;6.28,-6.09,;6.28,-7.63,;7.61,-5.32,;8.95,-6.09,;-.94,1.15,;-2.28,.38,)| Show InChI InChI=1S/C31H40Cl2N6O5/c1-6-25(40)38-18-21(19-38)44-14-13-39-29-20(17-35-31(36-29)34-11-9-10-12-37(7-2)8-3)15-22(30(39)41)26-27(32)23(42-4)16-24(43-5)28(26)33/h6,15-17,21H,1,7-14,18-19H2,2-5H3,(H,34,35,36)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.5	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim Pharmaceuticals Inc.					Assay Description A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...				Bioorg Med Chem Lett 19: 773-7 (2009) BindingDB Entry DOI: 10.7270/Q2GX4DVZ
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	US11078199, Cpd 103 (8-(2-((1-acryloylazetidin-3-yl)oxy)ethyl)-6-(2,6-d...) Show SMILES CCN(CC)CCCCNc1ncc2cc(-c3c(Cl)c(OC)cc(OC)c3Cl)c(=O)n(CCOC3CN(C3)C(=O)C=C)c2n1 |(-8.95,-8.09,;-8.95,-6.55,;-7.61,-5.78,;-6.28,-6.55,;-6.28,-8.09,;-7.61,-4.24,;-6.28,-3.47,;-6.28,-1.93,;-4.94,-1.16,;-4.94,.38,;-3.61,1.15,;-3.61,2.69,;-2.28,3.46,;-.94,2.69,;.39,3.46,;1.72,2.69,;3.06,3.46,;3.06,5,;1.72,5.77,;4.39,5.78,;4.39,7.32,;5.73,8.09,;5.73,5,;5.73,3.46,;7.06,2.69,;8.39,3.46,;4.39,2.69,;4.39,1.15,;1.72,1.15,;3.06,.38,;.39,.38,;.39,-1.16,;1.72,-1.93,;1.72,-3.47,;3.06,-4.24,;3.46,-5.72,;4.94,-5.32,;4.55,-3.84,;6.28,-6.09,;6.28,-7.63,;7.61,-5.32,;8.95,-6.09,;-.94,1.15,;-2.28,.38,)| Show InChI InChI=1S/C31H40Cl2N6O5/c1-6-25(40)38-18-21(19-38)44-14-13-39-29-20(17-35-31(36-29)34-11-9-10-12-37(7-2)8-3)15-22(30(39)41)26-27(32)23(42-4)16-24(43-5)28(26)33/h6,15-17,21H,1,7-14,18-19H2,2-5H3,(H,34,35,36)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	1.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM287555 (8-(2-((1-acryloylazetidin-3-yl)oxy)ethyl)-6-(2,6-d...) Show SMILES CCN(CC)CCCCNc1ncc2cc(-c3c(Cl)c(OC)cc(OC)c3Cl)c(=O)n(CCOC3CN(C3)C(=O)C=C)c2n1 |(-8.95,-8.09,;-8.95,-6.55,;-7.61,-5.78,;-6.28,-6.55,;-6.28,-8.09,;-7.61,-4.24,;-6.28,-3.47,;-6.28,-1.93,;-4.94,-1.16,;-4.94,.38,;-3.61,1.15,;-3.61,2.69,;-2.28,3.46,;-.94,2.69,;.39,3.46,;1.72,2.69,;3.06,3.46,;3.06,5,;1.72,5.77,;4.39,5.78,;4.39,7.32,;5.73,8.09,;5.73,5,;5.73,3.46,;7.06,2.69,;8.39,3.46,;4.39,2.69,;4.39,1.15,;1.72,1.15,;3.06,.38,;.39,.38,;.39,-1.16,;1.72,-1.93,;1.72,-3.47,;3.06,-4.24,;3.46,-5.72,;4.94,-5.32,;4.55,-3.84,;6.28,-6.09,;6.28,-7.63,;7.61,-5.32,;8.95,-6.09,;-.94,1.15,;-2.28,.38,)| Show InChI InChI=1S/C31H40Cl2N6O5/c1-6-25(40)38-18-21(19-38)44-14-13-39-29-20(17-35-31(36-29)34-11-9-10-12-37(7-2)8-3)15-22(30(39)41)26-27(32)23(42-4)16-24(43-5)28(26)33/h6,15-17,21H,1,7-14,18-19H2,2-5H3,(H,34,35,36)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.60	n/a	n/a	n/a	n/a	n/a	n/a
PRINCIPIA BIOPHARMA, INC. US Patent					Assay Description A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...				US Patent US9815834 (2017) BindingDB Entry DOI: 10.7270/Q2B85B83
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 2 (Homo sapiens (Human))	BDBM287555 (8-(2-((1-acryloylazetidin-3-yl)oxy)ethyl)-6-(2,6-d...) Show SMILES CCN(CC)CCCCNc1ncc2cc(-c3c(Cl)c(OC)cc(OC)c3Cl)c(=O)n(CCOC3CN(C3)C(=O)C=C)c2n1 |(-8.95,-8.09,;-8.95,-6.55,;-7.61,-5.78,;-6.28,-6.55,;-6.28,-8.09,;-7.61,-4.24,;-6.28,-3.47,;-6.28,-1.93,;-4.94,-1.16,;-4.94,.38,;-3.61,1.15,;-3.61,2.69,;-2.28,3.46,;-.94,2.69,;.39,3.46,;1.72,2.69,;3.06,3.46,;3.06,5,;1.72,5.77,;4.39,5.78,;4.39,7.32,;5.73,8.09,;5.73,5,;5.73,3.46,;7.06,2.69,;8.39,3.46,;4.39,2.69,;4.39,1.15,;1.72,1.15,;3.06,.38,;.39,.38,;.39,-1.16,;1.72,-1.93,;1.72,-3.47,;3.06,-4.24,;3.46,-5.72,;4.94,-5.32,;4.55,-3.84,;6.28,-6.09,;6.28,-7.63,;7.61,-5.32,;8.95,-6.09,;-.94,1.15,;-2.28,.38,)| Show InChI InChI=1S/C31H40Cl2N6O5/c1-6-25(40)38-18-21(19-38)44-14-13-39-29-20(17-35-31(36-29)34-11-9-10-12-37(7-2)8-3)15-22(30(39)41)26-27(32)23(42-4)16-24(43-5)28(26)33/h6,15-17,21H,1,7-14,18-19H2,2-5H3,(H,34,35,36)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.60	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim Pharmaceuticals Inc.					Assay Description The cell-based effects of FGFR inhibitors were determined by measuring inhibition of FGFR-dependent cell line growth. The cell lines SNU-16 was used ...				Bioorg Med Chem Lett 19: 773-7 (2009) BindingDB Entry DOI: 10.7270/Q2GX4DVZ
					More data for this Ligand-Target Pair