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SMILES: CC(C)CN1[C@H](C)Cc2cc(ccc2[C@H]1c1c(F)cc(\C=C\C(O)=O)cc1F)-c1ccc2cnccc2c1

InChI Key: InChIKey=RGGNWIZUQYXUNF-GQFIXPPISA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 288681   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
G-protein coupled estrogen receptor 1


(Homo sapiens (Human))		BDBM288681
PNG
(US10087191, Example 98)
Show SMILES CC(C)CN1[C@H](C)Cc2cc(ccc2[C@H]1c1c(F)cc(\C=C\C(O)=O)cc1F)-c1ccc2cnccc2c1 |r|
Show InChI InChI=1S/C32H30F2N2O2/c1-19(2)18-36-20(3)12-26-16-23(22-5-6-25-17-35-11-10-24(25)15-22)7-8-27(26)32(36)31-28(33)13-21(14-29(31)34)4-9-30(37)38/h4-11,13-17,19-20,32H,12,18H2,1-3H3,(H,37,38)/b9-4+/t20-,32+/m1/s1
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antibodypedia
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PC cid
PC sid
UniChem
US Patent
n/an/a 0.850n/an/an/an/an/an/a



Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
The compounds of the present invention have an inhibition effect on the binding of E (estrogen) to ER (estrogen receptor), thereby blocking the bindi...

US Patent US10087191 (2018)


BindingDB Entry DOI: 10.7270/Q2BP04T1
More data for this
Ligand-Target Pair