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SMILES: [2H]C([2H])(F)C([2H])([2H])Oc1cn(nc(-c2ccnn2-c2ccccc2)c1=O)-c1ccc(cc1F)C1CCOCC1

InChI Key: InChIKey=RPDUPLFOPDEGSF-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 291105   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))		BDBM291105
PNG
(5-(2-fluoro- ethyloxy-d4)-1-(2- fluoro-4- (tetrahy...)
Show SMILES [2H]C([2H])(F)C([2H])([2H])Oc1cn(nc(-c2ccnn2-c2ccccc2)c1=O)-c1ccc(cc1F)C1CCOCC1
Show InChI InChI=1S/C26H24F2N4O3/c27-11-15-35-24-17-31(22-7-6-19(16-21(22)28)18-9-13-34-14-10-18)30-25(26(24)33)23-8-12-29-32(23)20-4-2-1-3-5-20/h1-8,12,16-18H,9-11,13-15H2
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MMDB

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US Patent
n/an/a<10n/an/an/an/a7.425



TAKEDA PHARMACEUTICAL COMPANY LIMITED

US Patent


Assay Description
Human PDE1A, 3A, 4D2, 5A1, 7B, 8A1, 9A2, and 11A4 enzymes were purchased from BPS Bioscience. Human PDE6AB enzyme was purchased from Scottish Biomedi...

US Patent US9579407 (2017)


BindingDB Entry DOI: 10.7270/Q2FB5502
More data for this
Ligand-Target Pair