BDBM291357 2,8-Bis-(1H-indol-4-yl)-4-morpholin-4-yl-pyrido[3′,2′:4,5]furo[3,2-d]pyrimidine::US9580442, Example E::US9938290, E

SMILES: C1CN(CCO1)c1nc(nc2c3cc(cnc3oc12)-c1cccc2[nH]ccc12)-c1cccc2[nH]ccc12

InChI Key: InChIKey=GQKBNRLKAFHREP-UHFFFAOYSA-N

Data: 8 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 291357   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM291357 (2,8-Bis-(1H-indol-4-yl)-4-morpholin-4-yl-pyrido[3&...) Show SMILES C1CN(CCO1)c1nc(nc2c3cc(cnc3oc12)-c1cccc2[nH]ccc12)-c1cccc2[nH]ccc12 Show InChI InChI=1S/C29H22N6O2/c1-3-18(19-7-9-30-23(19)5-1)17-15-22-25-26(37-29(22)32-16-17)28(35-11-13-36-14-12-35)34-27(33-25)21-4-2-6-24-20(21)8-10-31-24/h1-10,15-16,30-31H,11-14H2	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	88	n/a	n/a	n/a	n/a	n/a	n/a
Karus Therapeutics Limited US Patent					Assay Description PI3K Isoform using biochemical assay.				US Patent US9580442 (2017) BindingDB Entry DOI: 10.7270/Q2J38VM2
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (Homo sapiens (Human))	BDBM291357 (2,8-Bis-(1H-indol-4-yl)-4-morpholin-4-yl-pyrido[3&...) Show SMILES C1CN(CCO1)c1nc(nc2c3cc(cnc3oc12)-c1cccc2[nH]ccc12)-c1cccc2[nH]ccc12 Show InChI InChI=1S/C29H22N6O2/c1-3-18(19-7-9-30-23(19)5-1)17-15-22-25-26(37-29(22)32-16-17)28(35-11-13-36-14-12-35)34-27(33-25)21-4-2-6-24-20(21)8-10-31-24/h1-10,15-16,30-31H,11-14H2	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	69	n/a	n/a	n/a	n/a	n/a	n/a
Karus Therapeutics Limited US Patent					Assay Description PI3K Isoform using biochemical assay.				US Patent US9580442 (2017) BindingDB Entry DOI: 10.7270/Q2J38VM2
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM291357 (2,8-Bis-(1H-indol-4-yl)-4-morpholin-4-yl-pyrido[3&...) Show SMILES C1CN(CCO1)c1nc(nc2c3cc(cnc3oc12)-c1cccc2[nH]ccc12)-c1cccc2[nH]ccc12 Show InChI InChI=1S/C29H22N6O2/c1-3-18(19-7-9-30-23(19)5-1)17-15-22-25-26(37-29(22)32-16-17)28(35-11-13-36-14-12-35)34-27(33-25)21-4-2-6-24-20(21)8-10-31-24/h1-10,15-16,30-31H,11-14H2	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
Karus Therapeutics Limited US Patent					Assay Description PI3K Isoform using biochemical assay.				US Patent US9580442 (2017) BindingDB Entry DOI: 10.7270/Q2J38VM2
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (Homo sapiens (Human))	BDBM291357 (2,8-Bis-(1H-indol-4-yl)-4-morpholin-4-yl-pyrido[3&...) Show SMILES C1CN(CCO1)c1nc(nc2c3cc(cnc3oc12)-c1cccc2[nH]ccc12)-c1cccc2[nH]ccc12 Show InChI InChI=1S/C29H22N6O2/c1-3-18(19-7-9-30-23(19)5-1)17-15-22-25-26(37-29(22)32-16-17)28(35-11-13-36-14-12-35)34-27(33-25)21-4-2-6-24-20(21)8-10-31-24/h1-10,15-16,30-31H,11-14H2	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	627	n/a	n/a	n/a	n/a	n/a	n/a
Lek Pharmaceuticals d.d.					Assay Description Please see article				J Med Chem 51: 7486-94 (2008) BindingDB Entry DOI: 10.7270/Q21V5H9P
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM291357 (2,8-Bis-(1H-indol-4-yl)-4-morpholin-4-yl-pyrido[3&...) Show SMILES C1CN(CCO1)c1nc(nc2c3cc(cnc3oc12)-c1cccc2[nH]ccc12)-c1cccc2[nH]ccc12 Show InChI InChI=1S/C29H22N6O2/c1-3-18(19-7-9-30-23(19)5-1)17-15-22-25-26(37-29(22)32-16-17)28(35-11-13-36-14-12-35)34-27(33-25)21-4-2-6-24-20(21)8-10-31-24/h1-10,15-16,30-31H,11-14H2	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	88	n/a	n/a	n/a	n/a	n/a	n/a
Lek Pharmaceuticals d.d.					Assay Description Please see article				J Med Chem 51: 7486-94 (2008) BindingDB Entry DOI: 10.7270/Q21V5H9P
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (Homo sapiens (Human))	BDBM291357 (2,8-Bis-(1H-indol-4-yl)-4-morpholin-4-yl-pyrido[3&...) Show SMILES C1CN(CCO1)c1nc(nc2c3cc(cnc3oc12)-c1cccc2[nH]ccc12)-c1cccc2[nH]ccc12 Show InChI InChI=1S/C29H22N6O2/c1-3-18(19-7-9-30-23(19)5-1)17-15-22-25-26(37-29(22)32-16-17)28(35-11-13-36-14-12-35)34-27(33-25)21-4-2-6-24-20(21)8-10-31-24/h1-10,15-16,30-31H,11-14H2	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	69	n/a	n/a	n/a	n/a	n/a	n/a
Lek Pharmaceuticals d.d.					Assay Description Please see article				J Med Chem 51: 7486-94 (2008) BindingDB Entry DOI: 10.7270/Q21V5H9P
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM291357 (2,8-Bis-(1H-indol-4-yl)-4-morpholin-4-yl-pyrido[3&...) Show SMILES C1CN(CCO1)c1nc(nc2c3cc(cnc3oc12)-c1cccc2[nH]ccc12)-c1cccc2[nH]ccc12 Show InChI InChI=1S/C29H22N6O2/c1-3-18(19-7-9-30-23(19)5-1)17-15-22-25-26(37-29(22)32-16-17)28(35-11-13-36-14-12-35)34-27(33-25)21-4-2-6-24-20(21)8-10-31-24/h1-10,15-16,30-31H,11-14H2	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
Lek Pharmaceuticals d.d.					Assay Description Please see article				J Med Chem 51: 7486-94 (2008) BindingDB Entry DOI: 10.7270/Q21V5H9P
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (Homo sapiens (Human))	BDBM291357 (2,8-Bis-(1H-indol-4-yl)-4-morpholin-4-yl-pyrido[3&...) Show SMILES C1CN(CCO1)c1nc(nc2c3cc(cnc3oc12)-c1cccc2[nH]ccc12)-c1cccc2[nH]ccc12 Show InChI InChI=1S/C29H22N6O2/c1-3-18(19-7-9-30-23(19)5-1)17-15-22-25-26(37-29(22)32-16-17)28(35-11-13-36-14-12-35)34-27(33-25)21-4-2-6-24-20(21)8-10-31-24/h1-10,15-16,30-31H,11-14H2	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	627	n/a	n/a	n/a	n/a	n/a	n/a
Karus Therapeutics Limited US Patent					Assay Description PI3K Isoform using biochemical assay.				US Patent US9580442 (2017) BindingDB Entry DOI: 10.7270/Q2J38VM2
					More data for this Ligand-Target Pair