BindingDB PrimarySearch

BDBM291359 (E)-3-[2-(1H-Indol-4-yl)-4-morpholin-4-yl-pyrido[3′,2′:4,5]furo[3,2-d]pyrimidin-8-yl]-N,N-dimethylacrylamide::US9580442, Example G::US9938290, G

SMILES: CN(C)C(=O)\C=C\c1cnc2oc3c(nc(nc3c2c1)-c1cccc2[nH]ccc12)N1CCOCC1

InChI Key: InChIKey=MMCLGQOGMBMOJC-VOTSOKGWSA-N

Data: 8 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 291359
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM291359 ((E)-3-[2-(1H-Indol-4-yl)-4-morpholin-4-yl-pyrido[3...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	223	n/a	n/a	n/a	n/a	n/a	n/a
Karus Therapeutics Limited US Patent					Assay Description PI3K Isoform using biochemical assay.				US Patent US9580442 (2017) BindingDB Entry DOI: 10.7270/Q2J38VM2
Karus Therapeutics Limited US Patent					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (Homo sapiens (Human))	BDBM291359 ((E)-3-[2-(1H-Indol-4-yl)-4-morpholin-4-yl-pyrido[3...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	83	n/a	n/a	n/a	n/a	n/a	n/a
Karus Therapeutics Limited US Patent					Assay Description PI3K Isoform using biochemical assay.				US Patent US9580442 (2017) BindingDB Entry DOI: 10.7270/Q2J38VM2
Karus Therapeutics Limited US Patent					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM291359 ((E)-3-[2-(1H-Indol-4-yl)-4-morpholin-4-yl-pyrido[3...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Karus Therapeutics Limited US Patent					Assay Description PI3K Isoform using biochemical assay.				US Patent US9580442 (2017) BindingDB Entry DOI: 10.7270/Q2J38VM2
Karus Therapeutics Limited US Patent					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (Homo sapiens (Human))	BDBM291359 ((E)-3-[2-(1H-Indol-4-yl)-4-morpholin-4-yl-pyrido[3...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.66E+3	n/a	n/a	n/a	n/a	n/a	n/a
Lek Pharmaceuticals d.d.					Assay Description Please see article				J Med Chem 51: 7486-94 (2008) BindingDB Entry DOI: 10.7270/Q21V5H9P
Lek Pharmaceuticals d.d.					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM291359 ((E)-3-[2-(1H-Indol-4-yl)-4-morpholin-4-yl-pyrido[3...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	223	n/a	n/a	n/a	n/a	n/a	n/a
Lek Pharmaceuticals d.d.					Assay Description Please see article				J Med Chem 51: 7486-94 (2008) BindingDB Entry DOI: 10.7270/Q21V5H9P
Lek Pharmaceuticals d.d.					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (Homo sapiens (Human))	BDBM291359 ((E)-3-[2-(1H-Indol-4-yl)-4-morpholin-4-yl-pyrido[3...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	83	n/a	n/a	n/a	n/a	n/a	n/a
Lek Pharmaceuticals d.d.					Assay Description Please see article				J Med Chem 51: 7486-94 (2008) BindingDB Entry DOI: 10.7270/Q21V5H9P
Lek Pharmaceuticals d.d.					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM291359 ((E)-3-[2-(1H-Indol-4-yl)-4-morpholin-4-yl-pyrido[3...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Lek Pharmaceuticals d.d.					Assay Description Please see article				J Med Chem 51: 7486-94 (2008) BindingDB Entry DOI: 10.7270/Q21V5H9P
Lek Pharmaceuticals d.d.					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (Homo sapiens (Human))	BDBM291359 ((E)-3-[2-(1H-Indol-4-yl)-4-morpholin-4-yl-pyrido[3...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.66E+3	n/a	n/a	n/a	n/a	n/a	n/a
Karus Therapeutics Limited US Patent					Assay Description PI3K Isoform using biochemical assay.				US Patent US9580442 (2017) BindingDB Entry DOI: 10.7270/Q2J38VM2
Karus Therapeutics Limited US Patent					More data for this Ligand-Target Pair