null

SMILES: Nc1ncnc(OC2CC3(C2)CN(C3)C(=O)C=C)c1-c1cnn(Cc2ccccc2)c1

InChI Key: InChIKey=IMSYTSBMKMBQFG-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 291394   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase BTK (Homo sapiens (Human))	BDBM291394 (1-(6-((6-amino-5-(1-benzyl-1H-pyrazol-4-yl)pyrimid...) Show SMILES Nc1ncnc(OC2CC3(C2)CN(C3)C(=O)C=C)c1-c1cnn(Cc2ccccc2)c1 Show InChI InChI=1S/C23H24N6O2/c1-2-19(30)28-13-23(14-28)8-18(9-23)31-22-20(21(24)25-15-26-22)17-10-27-29(12-17)11-16-6-4-3-5-7-16/h2-7,10,12,15,18H,1,8-9,11,13-14H2,(H2,24,25,26)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Merck Patent GmbH US Patent					Assay Description 2.5× stocks of full-length human BTK (08-080) from CarnaBio USA, Inc., Natick, Mass., 1.6×ATP and appropriate kinKDR peptide substrate (FITC-AHA-EEPL...				US Patent US10413562 (2019) BindingDB Entry DOI: 10.7270/Q27M0B95
					More data for this Ligand-Target Pair
Tyrosine-protein kinase BTK (Homo sapiens (Human))	BDBM291394 (1-(6-((6-amino-5-(1-benzyl-1H-pyrazol-4-yl)pyrimid...) Show SMILES Nc1ncnc(OC2CC3(C2)CN(C3)C(=O)C=C)c1-c1cnn(Cc2ccccc2)c1 Show InChI InChI=1S/C23H24N6O2/c1-2-19(30)28-13-23(14-28)8-18(9-23)31-22-20(21(24)25-15-26-22)17-10-27-29(12-17)11-16-6-4-3-5-7-16/h2-7,10,12,15,18H,1,8-9,11,13-14H2,(H2,24,25,26)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	7.5	27
Merck Patent GmbH US Patent					Assay Description The following describes a microfluidic, off-chip mobility shift kinase assay used to measure inherent potency of compounds against BTK enzyme. Compou...				US Patent US9580449 (2017) BindingDB Entry DOI: 10.7270/Q28K7C4Z
					More data for this Ligand-Target Pair