BDBM292713 1-(5-Butoxy-2-chlorophenyl)-8-chloro-3-methyl-1H-pyrazolo[4,3-c][1,5]naphthyridin-4(5H)-one::US10105349, Example 20::US10543194, Example 20
SMILES: CCCCOc1ccc(Cl)c(c1)-n1nc(C)c2c1c1nc(Cl)ccc1[nH]c2=O
InChI Key: InChIKey=PCAMJUDIUZGFAB-UHFFFAOYSA-N
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Homo sapiens phosphodiesterase 2A (PDE2A) (Homo sapiens (Human)) | BDBM292713 (1-(5-Butoxy-2-chlorophenyl)-8-chloro-3-methyl-1H-p...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
INTRA-CELLULAR THERAPIES, INC. US Patent | Assay Description r-hPDE2A (Accession No. NM_002599, Homo sapiens phosphodiesterase 2A, cGMP-stimulated, transcript variant 1) A mammalian expression cloning vector wi... | US Patent US10543194 (2020) BindingDB Entry DOI: 10.7270/Q2F47RJZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Homo sapiens phosphodiesterase 2A (PDE2A) (Homo sapiens (Human)) | BDBM292713 (1-(5-Butoxy-2-chlorophenyl)-8-chloro-3-methyl-1H-p...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 12 | n/a | n/a | n/a | n/a | 7.2 | 25 |
INTRA-CELLULAR THERAPIES, INC. US Patent | Assay Description Assay: PDE2A is assayed with FL-cAMP as substrate. An enzyme titration is first performed to determine the working concentration of PDE. The concentr... | US Patent US10105349 (2018) BindingDB Entry DOI: 10.7270/Q2QN68T1 | |||||||||||
More data for this Ligand-Target Pair |