BDBM292714 1-(5-Butoxy-2-chlorophenyl)-3-methyl-1H-pyrazolo[4,3-c][1,5]naphthyridin-4(5H)-one::US10105349, Example 17::US10543194, Example 17

SMILES: CCCCOc1ccc(Cl)c(c1)-n1nc(C)c2c1c1ncccc1[nH]c2=O

InChI Key: InChIKey=WULNWHUMCHVZIE-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 292714   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Homo sapiens phosphodiesterase 2A (PDE2A) (Homo sapiens (Human))	BDBM292714 (1-(5-Butoxy-2-chlorophenyl)-3-methyl-1H-pyrazolo[4...) Show SMILES CCCCOc1ccc(Cl)c(c1)-n1nc(C)c2c1c1ncccc1[nH]c2=O Show InChI InChI=1S/C20H19ClN4O2/c1-3-4-10-27-13-7-8-14(21)16(11-13)25-19-17(12(2)24-25)20(26)23-15-6-5-9-22-18(15)19/h5-9,11H,3-4,10H2,1-2H3,(H,23,26)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	28	n/a	n/a	n/a	n/a	n/a	n/a
INTRA-CELLULAR THERAPIES, INC. US Patent					Assay Description r-hPDE2A (Accession No. NM_002599, Homo sapiens phosphodiesterase 2A, cGMP-stimulated, transcript variant 1) A mammalian expression cloning vector wi...				US Patent US10543194 (2020) BindingDB Entry DOI: 10.7270/Q2F47RJZ
					More data for this Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A) (Homo sapiens (Human))	BDBM292714 (1-(5-Butoxy-2-chlorophenyl)-3-methyl-1H-pyrazolo[4...) Show SMILES CCCCOc1ccc(Cl)c(c1)-n1nc(C)c2c1c1ncccc1[nH]c2=O Show InChI InChI=1S/C20H19ClN4O2/c1-3-4-10-27-13-7-8-14(21)16(11-13)25-19-17(12(2)24-25)20(26)23-15-6-5-9-22-18(15)19/h5-9,11H,3-4,10H2,1-2H3,(H,23,26)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	28	n/a	n/a	n/a	n/a	7.2	25
INTRA-CELLULAR THERAPIES, INC. US Patent					Assay Description Assay: PDE2A is assayed with FL-cAMP as substrate. An enzyme titration is first performed to determine the working concentration of PDE. The concentr...				US Patent US10105349 (2018) BindingDB Entry DOI: 10.7270/Q2QN68T1
					More data for this Ligand-Target Pair