BDBM295029 3-{6-Amino-5-[1-(2,2,2-trifluoro-ethyl)-1H-pyrazol-4-yl]-pyridin-3-yl}-4-methyl-N-(6-methyl-pyridin-2-yl)-benzenesulfonamide::US10112926, Example 1
SMILES: Cc1cccc(NS(=O)(=O)c2ccc(C)c(c2)-c2cnc(N)c(c2)-c2cnn(CC(F)(F)F)c2)n1
InChI Key: InChIKey=NSTFOXCDXMJUGH-UHFFFAOYSA-N
Data: 7 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
PI3-kinase class I (Homo sapiens (Human)) | BDBM295029 (3-{6-Amino-5-[1-(2,2,2-trifluoro-ethyl)-1H-pyrazol...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 190 | n/a | n/a | n/a | n/a | 7.5 | 25 |
Novartis AG US Patent | Assay Description The luminescence-based ATP detection reagent KinaseGlo was obtained from Promega, (Cat. No. V6714, Lot No. 236161) through Catalys, Wallisellen, Swit... | US Patent US10112926 (2018) BindingDB Entry DOI: 10.7270/Q22R3TQ9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (Homo sapiens (Human)) | BDBM295029 (3-{6-Amino-5-[1-(2,2,2-trifluoro-ethyl)-1H-pyrazol...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 4.05E+3 | n/a | n/a | n/a | n/a | 7.5 | 25 |
Novartis AG US Patent | Assay Description The luminescence-based ATP detection reagent KinaseGlo was obtained from Promega, (Cat. No. V6714, Lot No. 236161) through Catalys, Wallisellen, Swit... | US Patent US10112926 (2018) BindingDB Entry DOI: 10.7270/Q22R3TQ9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphatidylinositol 3-kinase catalytic subunit type 3 (Homo sapiens (Human)) | BDBM295029 (3-{6-Amino-5-[1-(2,2,2-trifluoro-ethyl)-1H-pyrazol...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | >9.10E+3 | n/a | n/a | n/a | n/a | 7.5 | 25 |
Novartis AG US Patent | Assay Description The luminescence-based ATP detection reagent KinaseGlo was obtained from Promega, (Cat. No. V6714, Lot No. 236161) through Catalys, Wallisellen, Swit... | US Patent US10112926 (2018) BindingDB Entry DOI: 10.7270/Q22R3TQ9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase mTOR (Homo sapiens (Human)) | BDBM295029 (3-{6-Amino-5-[1-(2,2,2-trifluoro-ethyl)-1H-pyrazol...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 2.37E+3 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Novartis AG US Patent | Assay Description Binding Assays are based on the binding and displacement of an Alexa Fluor 647-labeled, ATP-competitive kinase inhibitors to the kinase of interest. ... | US Patent US10112926 (2018) BindingDB Entry DOI: 10.7270/Q22R3TQ9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (Homo sapiens (Human)) | BDBM295029 (3-{6-Amino-5-[1-(2,2,2-trifluoro-ethyl)-1H-pyrazol...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 7 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Novartis AG US Patent | Assay Description The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad, Calif., USA) (Cat. No. PV5099). The kit contains t... | US Patent US10112926 (2018) BindingDB Entry DOI: 10.7270/Q22R3TQ9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human)) | BDBM295029 (3-{6-Amino-5-[1-(2,2,2-trifluoro-ethyl)-1H-pyrazol...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 170 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Novartis AG US Patent | Assay Description The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad, Calif., USA) (Cat. No. PV5099). The kit contains t... | US Patent US10112926 (2018) BindingDB Entry DOI: 10.7270/Q22R3TQ9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphatidylinositol 4-kinase beta (Homo sapiens (Human)) | BDBM295029 (3-{6-Amino-5-[1-(2,2,2-trifluoro-ethyl)-1H-pyrazol...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.95E+3 | n/a | n/a | n/a | n/a | 7.5 | 25 |
Novartis AG US Patent | Assay Description The luminescence-based ATP detection reagent KinaseGlo was obtained from Promega, (Cat. No. V6714, Lot No. 236161) through Catalys, Wallisellen, Swit... | US Patent US10112926 (2018) BindingDB Entry DOI: 10.7270/Q22R3TQ9 | |||||||||||
More data for this Ligand-Target Pair |