BDBM29816 4-indolylamino-5-phenyl-3-pyridinecarbonitrile, 1c::CHEMBL513485

SMILES: COc1ccc(cc1OC)-c1cncc(C#N)c1Nc1cccc2[nH]ccc12

InChI Key: InChIKey=ALLMHFJXFWBPDH-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 29816   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Protein kinase C theta type (Homo sapiens (Human))	BDBM29816 (4-indolylamino-5-phenyl-3-pyridinecarbonitrile, 1c...) Show SMILES COc1ccc(cc1OC)-c1cncc(C#N)c1Nc1cccc2[nH]ccc12 Show InChI InChI=1S/C22H18N4O2/c1-27-20-7-6-14(10-21(20)28-2)17-13-24-12-15(11-23)22(17)26-19-5-3-4-18-16(19)8-9-25-18/h3-10,12-13,25H,1-2H3,(H,24,26)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	13	n/a	n/a	n/a	n/a	7.2	22
Wyeth Research					Assay Description All IC50s were measured by using a modified IMAP protocol from Molecular Devices. The kinase reaction was carried out in a Corning Costar 384 well pl...				Bioorg Med Chem Lett 19: 2461-3 (2009) Article DOI: 10.1016/j.bmcl.2009.03.053 BindingDB Entry DOI: 10.7270/Q21R6NVV
					More data for this Ligand-Target Pair
Protein kinase C delta type (Homo sapiens (Human))	BDBM29816 (4-indolylamino-5-phenyl-3-pyridinecarbonitrile, 1c...) Show SMILES COc1ccc(cc1OC)-c1cncc(C#N)c1Nc1cccc2[nH]ccc12 Show InChI InChI=1S/C22H18N4O2/c1-27-20-7-6-14(10-21(20)28-2)17-13-24-12-15(11-23)22(17)26-19-5-3-4-18-16(19)8-9-25-18/h3-10,12-13,25H,1-2H3,(H,24,26)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	62	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Inhibition of human PKCdelta by IMAP assay				Bioorg Med Chem Lett 19: 3623-6 (2009) Article DOI: 10.1016/j.bmcl.2009.04.126 BindingDB Entry DOI: 10.7270/Q29W0FD4
					More data for this Ligand-Target Pair
Protein kinase C theta type (Homo sapiens (Human))	BDBM29816 (4-indolylamino-5-phenyl-3-pyridinecarbonitrile, 1c...) Show SMILES COc1ccc(cc1OC)-c1cncc(C#N)c1Nc1cccc2[nH]ccc12 Show InChI InChI=1S/C22H18N4O2/c1-27-20-7-6-14(10-21(20)28-2)17-13-24-12-15(11-23)22(17)26-19-5-3-4-18-16(19)8-9-25-18/h3-10,12-13,25H,1-2H3,(H,24,26)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Inhibition of human PKCtheta by IMAP assay				Bioorg Med Chem Lett 19: 3623-6 (2009) Article DOI: 10.1016/j.bmcl.2009.04.126 BindingDB Entry DOI: 10.7270/Q29W0FD4
					More data for this Ligand-Target Pair