BDBM298321 (R)-3-[N-(3′-Chlorobiphenyl-4-ylmethyl)-N′-oxalythydrazino]-2-hydroxypropionic Acid::US10123984, Example 13::US10744104, Example 13
SMILES: O[C@H](CN(Cc1ccc(cc1)-c1cccc(Cl)c1)NC(=O)C(O)=O)C(O)=O
InChI Key: InChIKey=JYQAYNBQWZLMHO-OAHLLOKOSA-N
Data: 2 KI
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Neprilysin (Homo sapiens (Human)) | BDBM298321 ((R)-3-[N-(3′-Chlorobiphenyl-4-ylmethyl)-N...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | KEGG PC cid PC sid UniChem | US Patent | 3.55 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Theravance Biopharma R&D IP, LLC US Patent | Assay Description The assays were performed in 384-well white opaque plates at 37° C. using the fluorogenic peptide substrates at a concentration of 10 μM in Assa... | US Patent US10744104 (2020) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neprilysin (Homo sapiens (Human)) | BDBM298321 ((R)-3-[N-(3′-Chlorobiphenyl-4-ylmethyl)-N...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | KEGG PC cid PC sid UniChem | US Patent | 3.55 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
THERAVANCE BIOPHARMA R&D IP, LLC US Patent | Assay Description The assays were performed in 384-well white opaque plates at 37° C. using the fluorogenic peptide substrates at a concentration of 10 μM in Assa... | US Patent US10123984 (2018) BindingDB Entry DOI: 10.7270/Q2KK9DVB | |||||||||||
More data for this Ligand-Target Pair |