BDBM298359 (S)-1-((2S,4S)-1-(4-(benzyloxy)-3,5-dimethoxybenzoyl)-4-(trifluoromethyl)-pyrrolidine-2-carbonyl)pyrrolidine-2-carbonitrile::US10125097, Example 8::US10611727, Example 8

SMILES: COc1cc(cc(OC)c1OCc1ccccc1)C(=O)N1C[C@H](C[C@H]1C(=O)N1CCC[C@H]1C#N)C(F)(F)F

InChI Key: InChIKey=NGNSKOONGZXUQW-ACRUOGEOSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 298359   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Prolyl endopeptidase-like (Human)	BDBM298359 ((S)-1-((2S,4S)-1-(4-(benzyloxy)-3,5-dimethoxybenzo...) Show SMILES COc1cc(cc(OC)c1OCc1ccccc1)C(=O)N1C[C@H](C[C@H]1C(=O)N1CCC[C@H]1C#N)C(F)(F)F |r| Show InChI InChI=1S/C27H28F3N3O5/c1-36-22-11-18(12-23(37-2)24(22)38-16-17-7-4-3-5-8-17)25(34)33-15-19(27(28,29)30)13-21(33)26(35)32-10-6-9-20(32)14-31/h3-5,7-8,11-12,19-21H,6,9-10,13,15-16H2,1-2H3/t19-,20-,21-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	176	n/a	n/a	n/a	n/a	n/a	n/a
UNIVERSITAT DE BARCELONA; FUNACIÓ INSTITUT DE RECERCA BIOMÉDICA; IPROTEOS S.L. US Patent					Assay Description POP activity was determined following the method described by Toide et al (Toide K et al., J. Pharmacol. Exp. Ther. 1995; 274:1370-8), using Z-G-P-AM...				US Patent US10611727 (2020)
					More data for this Ligand-Target Pair
Prolyl endopeptidase (Homo sapiens (Human))	BDBM298359 ((S)-1-((2S,4S)-1-(4-(benzyloxy)-3,5-dimethoxybenzo...) Show SMILES COc1cc(cc(OC)c1OCc1ccccc1)C(=O)N1C[C@H](C[C@H]1C(=O)N1CCC[C@H]1C#N)C(F)(F)F |r| Show InChI InChI=1S/C27H28F3N3O5/c1-36-22-11-18(12-23(37-2)24(22)38-16-17-7-4-3-5-8-17)25(34)33-15-19(27(28,29)30)13-21(33)26(35)32-10-6-9-20(32)14-31/h3-5,7-8,11-12,19-21H,6,9-10,13,15-16H2,1-2H3/t19-,20-,21-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	176	n/a	n/a	n/a	n/a	n/a	n/a
UNIVERSITAT DE BARCELONA; FUNDACIO INSTITUT DE RECERCA BIOMEDICA (IRB BARCELONA); IPROTEOS S.L. US Patent					Assay Description POP activity was determined following the method described by Toide et al (Toide K et al., J. Pharmacol. Exp. Ther. 1995; 274:1370-8), using Z-G-P-AM...				US Patent US10125097 (2018) BindingDB Entry DOI: 10.7270/Q22J6DX3
					More data for this Ligand-Target Pair