BDBM298378 US10124003, Ex. Compound 56::US10835536, Ex. Comp 56

SMILES: CCN(C)C\C=C\C(=O)N1CC(C1)n1cc(C#Cc2cc(OC)cc(OC)c2)c2c(N)ncnc12

InChI Key: InChIKey=SRXSVELDZUDZDZ-VOTSOKGWSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 298378   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Fibroblast growth factor receptor 2 (Homo sapiens (Human))	BDBM298378 (US10124003, Ex. Compound 56 | US10835536, Ex. Comp...) Show SMILES CCN(C)C\C=C\C(=O)N1CC(C1)n1cc(C#Cc2cc(OC)cc(OC)c2)c2c(N)ncnc12 Show InChI InChI=1S/C26H30N6O3/c1-5-30(2)10-6-7-23(33)31-15-20(16-31)32-14-19(24-25(27)28-17-29-26(24)32)9-8-18-11-21(34-3)13-22(12-18)35-4/h6-7,11-14,17,20H,5,10,15-16H2,1-4H3,(H2,27,28,29)/b7-6+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.5	n/a	n/a	n/a	n/a	n/a	n/a
Taiho Pharmaceutical Co., Ltd. US Patent					Assay Description When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR2 kinase activity, FL-Peptide 22 (Caliper Life Sciences,...				US Patent US10835536 (2020)
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 2 (Homo sapiens (Human))	BDBM298378 (US10124003, Ex. Compound 56 | US10835536, Ex. Comp...) Show SMILES CCN(C)C\C=C\C(=O)N1CC(C1)n1cc(C#Cc2cc(OC)cc(OC)c2)c2c(N)ncnc12 Show InChI InChI=1S/C26H30N6O3/c1-5-30(2)10-6-7-23(33)31-15-20(16-31)32-14-19(24-25(27)28-17-29-26(24)32)9-8-18-11-21(34-3)13-22(12-18)35-4/h6-7,11-14,17,20H,5,10,15-16H2,1-4H3,(H2,27,28,29)/b7-6+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.5	n/a	n/a	n/a	n/a	n/a	n/a
Taiho Pharmaceutical Co., Ltd. US Patent					Assay Description When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR2 kinase activity, FL-Peptide 22 (Caliper Life Sciences,...				US Patent US10124003 (2018) BindingDB Entry DOI: 10.7270/Q2B27XBQ
					More data for this Ligand-Target Pair