null
SMILES: COCCOCCOCCNC(=O)c1ccc(Nc2cc(Oc3ccc(NC(=O)Nc4cc(cc(NS(C)(=O)=O)c4OC)C(C)(C)C)c4ccccc34)ccn2)cc1OC
InChI Key: InChIKey=KDSZOXKIGJOWQA-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mitogen-activated protein kinase 14 (Homo sapiens (Human)) | BDBM298380![]() (4-((4-((4-(3-(5-(tert-Butyl)-2-methoxy-3-(methylsu...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 119 | n/a | n/a | n/a | n/a | n/a | n/a |
Topivert Pharma Limited US Patent | Assay Description The inhibitory activities of test compounds against the p38 MAPKα isoform (MAPK14: Invitrogen) are evaluated indirectly by determining the level... | US Patent US10125100 (2018) BindingDB Entry DOI: 10.7270/Q2XW4MV4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glycogen synthase kinase-3 alpha (Homo sapiens (Human)) | BDBM298380![]() (4-((4-((4-(3-(5-(tert-Butyl)-2-methoxy-3-(methylsu...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.34E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Oxular Acquisitions Limited US Patent | Assay Description GSK 3α Method 2: The inhibitory activities of compounds of the invention against the GSK 3α enzyme isoform (Invitrogen), are evaluated by d... | US Patent US10941115 (2021) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase SYK (Homo sapiens (Human)) | BDBM298380![]() (4-((4-((4-(3-(5-(tert-Butyl)-2-methoxy-3-(methylsu...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 187 | n/a | n/a | n/a | n/a | n/a | n/a |
Topivert Pharma Limited US Patent | Assay Description The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), are evaluated in a similar fashion to that descri... | US Patent US10125100 (2018) BindingDB Entry DOI: 10.7270/Q2XW4MV4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glycogen synthase kinase-3 alpha (Homo sapiens (Human)) | BDBM298380![]() (4-((4-((4-(3-(5-(tert-Butyl)-2-methoxy-3-(methylsu...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.34E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Topivert Pharma Limited US Patent | Assay Description The inhibitory activities of compounds of the invention against the GSK 3α enzyme isoform (Invitrogen), are evaluated by determining the level o... | US Patent US10125100 (2018) BindingDB Entry DOI: 10.7270/Q2XW4MV4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase 14 (Homo sapiens (Human)) | BDBM298380![]() (4-((4-((4-(3-(5-(tert-Butyl)-2-methoxy-3-(methylsu...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 119 | n/a | n/a | n/a | n/a | n/a | n/a |
RESPIVERT LIMITED; TOPIVERT PHARMA LIMITED US Patent | Assay Description The inhibitory activities of compounds of the invention against p38MAPKγ (MAPK12: Invitrogen), are evaluated in a similar fashion to that descri... | US Patent US9751837 (2017) BindingDB Entry DOI: 10.7270/Q2028TP7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human)) | BDBM298380![]() (4-((4-((4-(3-(5-(tert-Butyl)-2-methoxy-3-(methylsu...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 31 | n/a | n/a | n/a | n/a | n/a | n/a |
RESPIVERT LIMITED; TOPIVERT PHARMA LIMITED US Patent | Assay Description The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), are evaluated in a similar fashion to that descri... | US Patent US9751837 (2017) BindingDB Entry DOI: 10.7270/Q2028TP7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase SYK (Homo sapiens (Human)) | BDBM298380![]() (4-((4-((4-(3-(5-(tert-Butyl)-2-methoxy-3-(methylsu...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 187 | n/a | n/a | n/a | n/a | n/a | n/a |
RESPIVERT LIMITED; TOPIVERT PHARMA LIMITED US Patent | Assay Description Method 1The inhibitory activities of compounds of the invention against the GSK 3α enzyme isoform (Invitrogen), are evaluated by determining the... | US Patent US9751837 (2017) BindingDB Entry DOI: 10.7270/Q2028TP7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glycogen synthase kinase-3 alpha (Homo sapiens (Human)) | BDBM298380![]() (4-((4-((4-(3-(5-(tert-Butyl)-2-methoxy-3-(methylsu...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.34E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
RESPIVERT LIMITED; TOPIVERT PHARMA LIMITED US Patent | US Patent US9751837 (2017) BindingDB Entry DOI: 10.7270/Q2028TP7 | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Baculoviral IAP repeat-containing protein 2 [174-256] (Homo sapiens (Human)) | BDBM298380![]() (4-((4-((4-(3-(5-(tert-Butyl)-2-methoxy-3-(methylsu...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 119 | n/a | n/a | n/a | n/a | n/a | n/a |
Topivert Pharma Limited US Patent | Assay Description p38 MAPKγ: The inhibitory activities of compounds of the invention against p38MAPKγ (MAPK12: Invitrogen), are evaluated in a similar fashio... | US Patent US10392346 (2019) BindingDB Entry DOI: 10.7270/Q2N018WV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human)) | BDBM298380![]() (4-((4-((4-(3-(5-(tert-Butyl)-2-methoxy-3-(methylsu...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 31 | n/a | n/a | n/a | n/a | n/a | n/a |
Topivert Pharma Limited US Patent | Assay Description c-Src and Syk: The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), are evaluated in a similar fashion... | US Patent US10392346 (2019) BindingDB Entry DOI: 10.7270/Q2N018WV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase SYK (Homo sapiens (Human)) | BDBM298380![]() (4-((4-((4-(3-(5-(tert-Butyl)-2-methoxy-3-(methylsu...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 187 | n/a | n/a | n/a | n/a | n/a | n/a |
Topivert Pharma Limited US Patent | Assay Description c-Src and Syk: The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), are evaluated in a similar fashion... | US Patent US10392346 (2019) BindingDB Entry DOI: 10.7270/Q2N018WV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glycogen synthase kinase-3 alpha (Homo sapiens (Human)) | BDBM298380![]() (4-((4-((4-(3-(5-(tert-Butyl)-2-methoxy-3-(methylsu...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.34E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Topivert Pharma Limited US Patent | Assay Description GSK 3α Method 2: This method follows the same steps as Method 1, but utilises a shorter period of mixing of the test compound (105 minutes inste... | US Patent US10392346 (2019) BindingDB Entry DOI: 10.7270/Q2N018WV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase 14 (Homo sapiens (Human)) | BDBM298380![]() (4-((4-((4-(3-(5-(tert-Butyl)-2-methoxy-3-(methylsu...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 119 | n/a | n/a | n/a | n/a | n/a | n/a |
Oxular Acquisitions Limited US Patent | Assay Description p38 MAPKα Method 2: The inhibitory activities of test compounds against the p38 MAPKα isoform (MAPK14: Invitrogen) are evaluated indirectly... | US Patent US10941115 (2021) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human)) | BDBM298380![]() (4-((4-((4-(3-(5-(tert-Butyl)-2-methoxy-3-(methylsu...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 31 | n/a | n/a | n/a | n/a | n/a | n/a |
Oxular Acquisitions Limited US Patent | Assay Description c-Src and Syk: The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), are evaluated in a similar fashion... | US Patent US10941115 (2021) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase SYK (Homo sapiens (Human)) | BDBM298380![]() (4-((4-((4-(3-(5-(tert-Butyl)-2-methoxy-3-(methylsu...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 187 | n/a | n/a | n/a | n/a | n/a | n/a |
Oxular Acquisitions Limited US Patent | Assay Description c-Src and Syk: The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), are evaluated in a similar fashion... | US Patent US10941115 (2021) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human)) | BDBM298380![]() (4-((4-((4-(3-(5-(tert-Butyl)-2-methoxy-3-(methylsu...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 31 | n/a | n/a | n/a | n/a | n/a | n/a |
Topivert Pharma Limited US Patent | Assay Description The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), are evaluated in a similar fashion to that descri... | US Patent US10125100 (2018) BindingDB Entry DOI: 10.7270/Q2XW4MV4 | |||||||||||
More data for this Ligand-Target Pair |