null
SMILES: COc1c(NC(=O)Nc2ccc(Oc3ccnc(Nc4ccc(cc4)C(O)=O)c3)c3ccccc23)cc(cc1NS(C)(=O)=O)C(C)(C)C
InChI Key: InChIKey=QVNARCRMXQXDGM-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Glycogen synthase kinase-3 alpha (Homo sapiens (Human)) | BDBM298414![]() (US10125100, Example 17(t) | US10392346, Example 17...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 140 | n/a | n/a | n/a | n/a | n/a | n/a |
Topivert Pharma Limited US Patent | Assay Description The inhibitory activities of compounds of the invention against the GSK 3α enzyme isoform (Invitrogen), are evaluated by determining the level o... | US Patent US10125100 (2018) BindingDB Entry DOI: 10.7270/Q2XW4MV4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glycogen synthase kinase-3 alpha (Homo sapiens (Human)) | BDBM298414![]() (US10125100, Example 17(t) | US10392346, Example 17...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 140 | n/a | n/a | n/a | n/a | n/a | n/a |
Oxular Acquisitions Limited US Patent | Assay Description GSK 3α Method 2: The inhibitory activities of compounds of the invention against the GSK 3α enzyme isoform (Invitrogen), are evaluated by d... | US Patent US10941115 (2021) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glycogen synthase kinase-3 alpha (Homo sapiens (Human)) | BDBM298414![]() (US10125100, Example 17(t) | US10392346, Example 17...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 140 | n/a | n/a | n/a | n/a | n/a | n/a |
Topivert Pharma Limited US Patent | Assay Description GSK 3α Method 2: This method follows the same steps as Method 1, but utilises a shorter period of mixing of the test compound (105 minutes inste... | US Patent US10392346 (2019) BindingDB Entry DOI: 10.7270/Q2N018WV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glycogen synthase kinase-3 alpha (Homo sapiens (Human)) | BDBM298414![]() (US10125100, Example 17(t) | US10392346, Example 17...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 140 | n/a | n/a | n/a | n/a | n/a | n/a |
RESPIVERT LIMITED; TOPIVERT PHARMA LIMITED US Patent | US Patent US9751837 (2017) BindingDB Entry DOI: 10.7270/Q2028TP7 | ||||||||||||
More data for this Ligand-Target Pair |